EDA-GTP-DY-647P1
excitation and emission spectrum of DY-647P1
For research use only.
Please centrifuge briefly before opening (volume ≤2 ml).
Shipping: shipped on gel packs
Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.
Shelf Life: 12 months after date of delivery
Molecular Formula: C47H62N9O23P3S2
Molecular Weight: 1278.09 g/mol (free acid)
Exact Mass: 1277.26 g/mol (free acid)
Purity: ≥ 95 % (HPLC)
Form: solution in water
Color: blue
Concentration: 1.0 mM - 1.1 mM
pH: 7.5 ±0.5
Spectroscopic Properties: λmax 653 nm, λem 670 nm, ε 250.0 L mmol-1 cm-1 (Tris-HCl pH 7.5)
Selected References:
Hillig et al. (2019) Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS–SOS1 interaction PNAS 116 (7):2551.
At this point, external content from bioz.com is embedded. When it loads, data (e.g. your IP address) is transmitted to the provider.
Scientific citations for Jena Bioscience nu-820-647p1
6 scientific citations and 0 citation images found by Bioz.
-
Substituted tricyclic compounds
, 2025-10-07 · DOI:
Compounds were pre-incubated with hSOS1 working solution containing 10-50 nM hSOS1 and
200 nM EDA-GTP-DY-647P1 (Custom manufactured,Jena Biosciences ) per well of a 384 well plate (Perkin Elmer, Cat #6007290) for 10 min at 20° C. in the assay buffer containing 10 mM HEPES, pH 7.4, 150 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.05% BSA fraction V and 0.0025% Igepal. -
Pyrimidine based modulators and uses thereof
, 2024-11-19 · DOI:
.. prevents SOS-mediated nucleotide exchange locks KRas in its inactive state.. Homogenous time resolved fluorescence (HTRF) was used to detect SOS-mediated binding of a fluorescent GTP analog, GTP-DY-647P1 (Jena Biosciences
NU-820-647P1 ) to GST-tagged KRAS-G12D (2-169, Reaction Biology, MSC-11-539) or to GST-tagged KRAS-G12V (2-169, Reaction Biology, MSC-11-540).. GST-tagged KRAS-G12D (2-169) and anti-GST MAb Tb Cryptate Gold (CisBio .. -
KRAS modulators and uses thereof
, 2024-02-27 · DOI:
.. in a manner that prevents SOS-mediated nucleotide exchange locks KRas in its inactive state.. Homogenous time resolved fluorescence (HTRF) was used to detect SOS-mediated binding of a fluorescent GTP analog, GTP-DY-647P1 (
Jena Biosciences NU-820-647P1 ) to GST-tagged KRASG12D (2-169, Reaction Biology, MSC-11-539).. GST-tagged KRASG12D (2-169) and anti-GST MAb Tb Cryptate Gold (CisBio 61GSTTLB) were diluted into ..
