2',5'-GpAp

For research use only.

Shipping: shipped on gel packs

Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.

Shelf Life: 12 months after date of delivery

Molecular Formula: C₂₀H₂₆N₁₀O₁₄P₂ (free acid)

Molecular Weight: 692.43 g/mol (free acid)

Exact Mass: 692.11 g/mol (free acid)

Purity: ≥ 98 % (HPLC) / ≤ 2.5 EU/ml Endotoxin (LAL test)

Form: solid (lyophilized from filtered (10 kDa) solution in water)

Color: white to off-white

Spectroscopic Properties: λ_max 260 nm, ε 25.0 L mmol^-1 cm^-1 (Tris-HCl pH 7.5)

Applications:
2’,5’-GpAp, also known as 2’,3’-cGAMP control, can be used as a negative control for 2’,3’-cGAMP due to its linear conformation.^[1]

Selected References:
[1] Ablasser et al. (2013) cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING. Nature 498(7454):380.