Cyclic Di- and Tri-Nucleotides

Cyclic dinucleotides (CDNs) and Cyclic trinucleotides (CTNs) consist of two or three nucleotides linked by phosphodiester bonds, forming a ring-like structure. Their unique architecture allows them to act as signaling molecules acrcoss diverse organisms with essential roles in bacterial communication and immune response activation.^[1-4]

Our CDNs and CTNs are endotoxin free (≤ 2.5 EU/ml by chromogenic LAL test) and thus ideally suited for cell culture applications.

[1] Wenzl et al. (2024) How enzyme-centered approaches are advancing research on cyclic oligo-nucleotides. FEBS Lett 598:839.
[2] Jenal et al. (2017) Cyclic di-GMP: second messenger extraordinaire. Nat. Rev. Microbiol. 15:271.
[3] Ablasser et al. (2013) cGAS produces a 2′‑5′‑linked cyclic dinucleotide second messenger that activates STING. Nature 498:380.
[4] Whiteley et al. (2019) Bacterial cGAS-like enzymes synthesize diverse nucleotide signals. Nature 567(7747):194.