cIMP

For general laboratory use.

Please centrifuge briefly before opening (volume ≤2 ml).

Shipping: shipped on gel packs

Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.

Shelf Life: 12 months after date of delivery

Molecular Formula: C₁₀H₁₁N₄O₇P (free acid)

Molecular Weight: 330.19 g/mol (free acid)

Exact Mass: 330.04 g/mol (free acid)

CAS#: 41092-64-2

Purity: ≥ 95 % (HPLC)

Form: solution in water

Color: colorless to slightly yellow

Concentration: 10 mM - 11 mM

pH: 7.5 ±0.5

Spectroscopic Properties: λ_max 249 nm, ε 12.2 L mmol^-1 cm^-1 (Tris-HCl pH 7.5)

BIOZ Product Citations:

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Selected References:
Wang et al. (2000) RNA polymerase-cNMP-ligated cAMP receptor protein (CRP) mutant interactions in the enhancement of transcription by CRP mutants. J. Biol. Chem. 275 (43):33457.
Shapiro et al. (2000) Structural basis for ligand selectivity of heteromeric olfactory cyclic nucleotide-gated channels. Biophys. J. 78 (5):2307.
Sunderman et al. (1999) Sequence of events underlying the allosteric transition of rod cyclic nucleotide-gated channels. J. Gen. Physiol. 113 (5):621.
Boadu et al. (1997) Binding characterization of a putative cGMP transporter in the cell membrane of human erythrocytes. Biochemistry-US 36 (36):10954.
Celeste et al. (1997) Identification of Critical Determinants for Autoinhibition in the Pseudosubstrate Region of Type Ia cAMP-dependent Protein Kinase. J. Biol. Chem. 272 (1):379.
Foster et al. (1996) Biochemical properties and cellular localization of the Drosophila DG1 cGMP-dependent protein kinase. J. Biol. Chem. 271 (38):23322.
Varnum et al. (1996) Subunit interactions in the activation of cyclic nucleotide-gated ion channels. Biophys. J. 70 (6):2667.
Reale et al. (1994) Nucleotide regulation of a calcium-activated cation channel in the rat insulinoma cell-line, CRI-G1. J. Membrane Biol. 141 (2):101.
Reddy (1978) Evidence for cyclic IMP as intracellular mediator of insulin action. Diabetes 27:499, Suppl. 2.
Agarwal et al. (1978) Effect of cyclic-GMP (cGMP) and cyclic IMP (cIMP) analogs on human platelet aggregation. Fed. Proc. 37 (3):546.