2',3'-cyclic nucleotide monophosphates (2′,3′-cNMPs) are single nucleotides with a phosphate group forming a bridge between the 2' and 3' hydroxyl groups of the ribose, creating a circular structure.
Functional roles in cell signaling have been discovered in both prokaryotes and eukaroytes.[1-7].
[1] Marotta et al. (2023) Insights into the metabolism, signaling, and physiological effects of 2’,3’-cyclic nucleotide monophosphates in bacteria. Critical Reviews in Biochemistry and Molecular Biology. 58(2-6):118.
[2] Chauhan et al. (2022) Binding of 2′,3′-Cyclic Nucleotide Monophosphates to Bacterial Ribosomes Inhibits Translation. ACS Cent. Sci. 8(11):1518.
[3] Duggal et al. (2022) Cellular Effects of 2′,3′-Cyclic Nucleotide Monophosphates in Gram-Negative Bacteria. ACS Cent. Sci. 204(1):e00208-21.
[4] Kosmacz et al. (2018) Interaction of 2′,3′-cAMP with Rbp47b plays a role in stress granule formation. Plant. Physiol. 177:411.
[5] Jackson et al. (2011) The 2′,3′-cAMP-adenosine pathway. Am. J. Physiol. Renal. Physiol. 301:F1160.
[6] Azarashvili et al. (2009) Ca2+-dependent permeability transition regulation in rat brain mitochondria by 2′,3′-cyclic nucleotides and 2′,3′-cyclic nucleotide 3′-phosphodiesterase. Am. J. Physiol. Cell Physiol. 296:C1428.
[7] Jia et al. (2009) A facile and sensitive method for quantification of cyclic nucleotide monophosphates in mammalian organs: basal levels of eight cNMPs and identification of 2′,3′-cIMP. Biomolecules 4:1070.
