N6-Methyl-adenosine-5'-triphosphate, Sodium salt
For research use only!
Shipping: shipped on blue ice
Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.
Shelf Life: 12 months after date of delivery
Molecular Formula: C11H18N5O13P3 (free acid)
Molecular Weight: 521.21 g/mol (free acid)
Exact Mass: 521.01 g/mol (free acid)
CAS#: 3130-39-0 (acid)
Purity: ≥ 95 % (HPLC)
Form: solution in water
Color: colorless to slightly yellow
Concentration: 100 mM - 110 mM
pH: 7.5 ±0.5
Spectroscopic Properties: λmax 265 nm, ε 18.5 L mmol-1 cm-1 (Tris-HCl pH 7.5)
Agonistic ligand, mainly for nucleoside receptor A1, with less affinity to A2A and A3
Nucleoside-triphosphates can be converted by different membrane-bound phosphatases into nucleosides acting as nucleoside receptor ligands. In some cases nucleoside phosphates act also directly on nucleoside receptors.
Agonist for P2Y receptor and for P2X2 purinoreceptor[2,3]
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Please click the black arrow on the right to expand the citation list. Click publication title for the full text.
 Brunstock et al. (1994) Structure activity relationships for derivatives of adenosine-5'-triphosphate as agonists at P2 purinoreceptors: heterogeneity within P2X and P2Y subtypes. Drug Dev. Res. 31 (3):206.
 Bo et al. (1994) Comparative studies on affinities of ATP derivatives for P2X-purinoreceptors in rat urinary bladder. Br. J. Pharmacol. 112 (4):1151.
 He et al. (2002) Purinergic P2X (2) receptor desensitization depends on coupling between ectodomain and C-terminal domain. Molec. Pharmac. 62 (5):1187.