AP3A - Solid
For research use only.
Shipping: shipped on gel packs
Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.
Shelf Life: 12 months after date of delivery
Molecular Formula: C20H27N10O16P3 (free acid)
Molecular Weight: 756.41 g/mol (free acid)
Exact Mass: 756.08 g/mol (free acid)
CAS#: 5959-90-0
Purity: ≥ 95 % (HPLC)
Form: solid
Color: white to off-white
Spectroscopic Properties: λmax 259 nm, ε 27.0 L mmol-1 cm-1 (Tris-HCl pH 7.5)
Specific Ligands:
Ligand for P2X and P2Y receptors:
Agonist at P2Y1 receptor[1,2,3], at P2Y12 and P2Y13 receptors[4] and for P2X1 - P2X4 purinoreceptors[5]
Selected References:
[1] Szczepanska-Konkel et al. (2005) Effects of diadenosine polyphosphates on glomerular volume. Br. J. Pharmacol. 144 (8):1109.
[2] Yerxa et al. (2001) P1- (uridine 5')-P4- (2'-deoxycytidine 5')tetraphosphate tetrasodiumsalt a next generation P2Y2 receptor agonist for treatment of cystic fibrosis. J. Pharmacol. Exp. Ther. 302:871.
[3] Ralevic et al. (2001) Structure-activity relationships of diadenosine polyphosphates (ApnAs), adenosine polyphospho guanosines (ApnGs) and guanosine polyphospho guanosines (GpnGs) at P2 receptors in the rat mesenteric arterial bed. Br. J. Pharmacol. 134 (5):1073.
[4] Zhang et al. (2002) Identification and characterization of a novel Gαi-coupled ADP receptor from human and mouse. J. Pharmacol. Exp. Ther. 301 (2):705.
[5] Gualix et al. (2014) Presence of diadenosine polyphosphates in microdialysis samples from rat cerebellum in vivo: effect of mild hyperammonemia on their receptors. Purinergic Signal. 10 (2):349.
Guranowski et al. (2000) Selective degradation of 2'-adenylated diadenosine tri- and tetraphosphates, Ap (3)A and Ap (4)A, by two specific human dinucleoside polyphosphate hydrolases. Arch. Biochem. Biophys. 373:218.
Luo et al. (1999) Identification and characterization of diadenosine 5',5'-P1,P2 -diphosphate and diadenosine 5',5'-P1,P3-triphosphate in human myocardial tissue. FASEB J. 13:695.
Luthje et al. (1988) Catabolism of Ap4A and Ap3A in whole blood. The dinucleotides are long-lived signal molecules in the blood ending up as intracellular ATP in the erythrocytes. Eur. J. Biochem. 173:241.
Luthje et al. (1987) Catabolism of Ap4A and Ap3A in human serum. Identification of isoenzymes and their partial characterization. Eur. J. Biochem. 169:385.
Luthje et al. (1985) Catabolism of Ap3A and Ap4A in human plasma. Purification and characterization of a glycoprotein complex with 5'-nucleotide phosphodiesterase activity. Eur. J. Biochem. 149:119.
Bochner et al. (1984) AppppA and related adenylylated nucleotides are synthesized as a consequence of oxidation stress. Cell 37 (1):225.
| Cat. No. | Amount | Price |
|---|---|---|
| NU-506-5 | 5 mg | 140,90 € |
| NU-506-25 | 25 mg | 564,00 € |
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Scientific citations for Jena Bioscience nu-506-lyo
4 scientific citations and 0 citation images found by Bioz.
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The Polypyrimidine Tract-Binding Protein Is a Transacting Factor for the Dengue Virus Internal Ribosome Entry Site
Viruses, 2024-11-09 · PMID:39599871
.. T7 NTP/CAP mix with a homemade 2X T7 NTP/ACAP mix.. The 2X T7 NTP/ACAP mix contained the A(
5′)ppp(5′)A-cap analog (# ) and NTPs (7.5 mM final concentration of CTP, ATP, UTP, and 1.5 mM final concentration of GTP; #R0471, #R0461, #R0451, #R0441, Thermo Fisher Scientific Inc.).. The transcription reactions were incubated for two hours at 37 ..NU-506-5 , Jena Bioscience, Jena, Thuringia, Germany -
The Mytilus chilensis Steamer-like Element-1 Retrotransposon Antisense mRNA Harbors an Internal Ribosome Entry Site That Is Modulated by hnRNPK
Viruses, 2024-03-05 · PMID:38543768
.. the addition of a poly(A) tail using a Poly(A) Tailing Kit (Ambion, Thermo Scientific).. The mRNAs with an unfunctional cap (Acap) were synthesized using mMESSAGE mMACHINE but substituting the capping buffers with a mix of rNTP and 40 mM A(5′)ppp(5′)A cap
analog ( ,NU-506-5 Jena Bioscience , Jena, Thuringia, Germany).. The uncapped RNAs were synthesized in the absence of any cap analog.The uncapped RNAs .. -
Two cGAS-like receptors induce antiviral immunity in Drosophila.
Nature, 2021-09-23 · PMID:34261128
.. liquid nitrogen and stored at −80 °C for further analysis.. Twenty nmol ATP-γ-S ( Jena Bioscience
NU-506-5
