cGMP

For general laboratory use.

Shipping: shipped on gel packs

Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.

Shelf Life: 12 months after date of delivery

Molecular Formula: C₁₀H₁₂N₅O₇P (free acid)

Molecular Weight: 345.21 g/mol (free acid)

Exact Mass: 345.05 g/mol (free acid)

CAS#: 40732-48-7

EC number: 255-056-0

Purity: ≥ 95 % (HPLC)

Form: solid

Spectroscopic Properties: λ_max 252 nm, ε 13.7 L mmol^-1 cm^-1 (Tris-HCl pH 7.5)

Selected References:
Nisoli et al. (2003) Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide. Science 299 (5608):896.
Ahumada et al. (2003) Signaling of rat Frizzled-2 through phosphodiesterase and cyclic GMP. Science 298 (5600):2006.
Rybalkin et al. (2003) PDE5 is converted to an activated state upon cGMP binding to the GAF A domain. EMBO J. 22 (3):469.
Butt et al. (2003) Actin binding of human LIM and SH3 protein (LASP) is regulated by cGMP- and cAMP-dependent protein kinase phosphorylation on Ser-146. J. Biol. Chem. 2003 Feb 5 [epub ahead of print].
Leckie et al. (2003) The NO pathway acts late during the fertilization response in sea urchin eggs. J. Biol Chem. 2003 Jan 22 [epub ahead of print]
Ludidi et al. (2003) Identification of a Novel Protein with Guanylyl Cyclase Activity in Arabidopsis thaliana. J. Biol Chem. 278 (8):6490.
Coates et al. (2002) Antagonistic pathways in neurons exposed to body fluid regulate social feeding in Caenorhabditis elegans. Nature 419 (6910):925.
Bosgraaf et al. (2002) A novel cGMP signalling pathway mediating myosin phosphorylation and chemotaxis in Dictyostelium. EMBO J. 21 (17):4560.
Higgins et al. (2002) Molecular architecture of a retinal cGMP-gated channel: the arrangement of the cytoplasmic domains. EMBO J. 21 (9):2087.
Castellani et al. (2002) Cis and trans interactions of L1 with neuropilin-1 control axonal responses to semaphorin 3A. EMBO J. 21 (23):6348.
Park et al. (2002) Nitric Oxide-Cyclic GMP Signaling Pathway in the Regulation of Rabbit Clitoral Cavernosum Tone. Exp. Biol. Med. (Maywood) 227 (11):1022.
Wenzl et al. (2024) How enzyme-centered approaches are advancing research on cyclic oligo-nucleotides. FEBS Lett.598(8): 839.