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5-Carboxy-dC

cadC, 5-Carboxy-2'-deoxycytidine

Cat. No. Amount Price (EUR) Buy / Note
N-1067-5 5 mg 143,97 Add to Basket/Quote Add to Notepad
Structural formula of 5-Carboxy-dC (cadC, 5-Carboxy-2'-deoxycytidine)
Structural formula of 5-Carboxy-dC

For research use only!

Shipping: shipped at ambient temperature

Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.

Shelf Life: 24 months after date of delivery

Molecular Formula: C10H13N3O6

Molecular Weight: 271.23 g/mol

Exact Mass: 271.08 g/mol

Purity: ≥ 95 % (HPLC)

Form: white to off-white powder

Solubility: water, methanol

Spectroscopic Properties: λmax 280 nm, ε 7.6 L mmol-1 cm-1 (Tris-HCl pH 7.5)

Applications:
Metabolism of dC substituted at position 5[1]
Incorporation into DNA[2]
functional and conformational influence of cytosine modifications[3]

Selected References:
[1] Schiesser (2013) Deamination, Oxidation, and C-C Bond Cleavage Reactivity of 5-Hydroxymethylcytosine, 5-Formylcytosine, and 5-Carboxycytosine. J. Am. Chem. Soc. 135:14593.
[2] Schroeder (2014) Synthesis of a DNA promoter segment containing all four epigenetic nucleosides: 5-Methyl-, 5-hydroxymethyl-, 5-formyl-, and 5-carboxy-2'-deoxycytidine. Angew. Chem. Int. Ed. 53: 315.
[3] Sumino (2008) Synthesis and properties of oligodeoxynucleotides containing 5-carboxy-2'-deoxycytidines. Bioorg. Med. Chem. Lett. 18:274.