For in vitro use only!
Shipping: shipped on blue ice
Storage Conditions: store at -20 °C
Shelf Life: 12 months after date of delivery
8-Oxo-Guanosines are used for random mutagenesis of DNA. 8-Oxo-dGTP can be incorporated by PCR but hybridizes with Adenosine instead of Cytidine.
The 8-Oxo-2'-deoxyguanosine Kit contains a set of 4 typical 8-Oxo-2'-deoxyguanosine analogs (Nucleoside, 5'-Mono, Di- and Triphosphate).
|8-Oxo-2'-Deoxy-Guanosine Analog||Cat. No.||Amount|
|8-Oxo-dGMP||NU-1153||50 μl (10 mM)|
|8-Oxo-dGDP||NU-1158||50 μl (10 mM)|
|8-Oxo-dGTP||NU-1117||50 μl (10 mM)|
Kai et al. (2002) An oxidized nucleotide affects DNA replication through activation of protein kinases in Xenopus egg lysates. Nucl. Acids Res. 30 (2):569.
Canitrot et al. (2000) Nucleotide excision repair DNA synthesis by excess DNA polymerase beta: a potential source of genetic instability in cancer cells. FASEB J. 14 (12):1765.
Nampalli et al. (2000) Efficient synthesis of 8-oxo-dGTP: A mutagenic nucleotide. Bioorg. Med. Chem. Lett. 10 (15):1677.