Inhibitor of DNA Methyltransferases
Ladakamycin, Mylosar, Vidaza
For research use only!
Shipping: shipped on blue ice
Storage Conditions: store at -20 °C
Shelf Life: 12 months after date of delivery
Molecular Formula: C8H12N4O5
Molecular Weight: 244.20 g/mol
Exact Mass: 244.08 g/mol
EC number: 206-280-2
Purity: ≥ 95 % (HPLC)
Form: white to off-white solid
For research use only!
5-Azacytidine is an inhibitor of DNA-methyltransferases that causes DNA-demethylation or hemi-demethylation. It regulates gene activation and silencing by creating openings that allow transcription factors to bind to DNA and thus for instance to reactivate tumor suppressor genes. 5-Azacytidine is a prodrug, which needs to be phosphorylated by cellular cytidine kinases. Resulting 5-Aza-dCTP is incorporated into DNA and traps the DNA methyltransferase in the progressing fork. 5-Azacytidine is used in treatment of several cancer diseases. IC50 = 2.4 to 2.6 μM for in vitro anti-myeloma activity (myelodysplastic syndrome) and 0.4 μM for inhibiting proliferation of various cancer cell lines.
Related products: Jena Bioscience offers additional inhibitors for DNA-methyltransferases: 5-Aza-2'dCTP (#NU-1118), 5-Azacytosine (#NU-960), 6-Thioguanine (#NU-962) and 6-Mercaptopurine (#NU-963). See also 5-Methyl-CTP and derivatives: #NU-1138, #N-1070, #NU-932, #NU-1125, #NU-1069 and #NU-1067.
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