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Azide-containing Ribo-nucleosides

Azide-containing nucleosides can be labeled with terminal Alkyne or strained Alkyne (e.g. DBCO)-tagged reporter molecules via a Cu(I)-catalyzed Alknye-Azide (CUAAC) or Cu(I)-free strain-promoted Alkyne-Azide Click Chemistry (SPAAC) reaction, respectively.

A number of cell-permeable CLICK-functionalized nucleosides are suitable for DNA synthesis monitoring → Click Chemistry, RNA synthesis monitoring → Click Chemistry, the analysis of poly A tail dynamics → Click Chemistry or Protein synthesis monitoring → Click Chemistry.