5-Formyl-dC

For general laboratory use.

Shipping: shipped at ambient temperature

Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.

Shelf Life: 24 months after date of delivery

Molecular Formula: C₁₀H₁₃N₃O₅

Molecular Weight: 255.23 g/mol

Exact Mass: 255.09 g/mol

CAS#: 137017-45-9

Purity: ≥ 95 % (HPLC)

Form: solid

Color: white to off-white

Spectroscopic Properties: λ_max 283 nm, ε 11.0 L mmol^-1 cm^-1 (Tris-HCl pH 7.5)

Applications:
Epigenetic research^[1]
Use in epigenetic therapy^[2]
Metabolism of dC substituted at position 5^[3,4]

BIOZ Product Citations:
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Selected References:
[1] Schroeder (2014) Synthesis of a DNA promoter segment containing all four epigenetic nucleosides: 5-Methyl-, 5-hydroxymethyl-, 5-formyl-, and 5-carboxy-2'-deoxycytidine. Angew. Chem. Int. Ed. 53:315.
[2] Zauri et al. (2015) CDA directs metabolism of epigenetic nucleosides revealing a therapeutic window in cancer. Nature 524:114.
[3] Schiesser et al. (2013) Deamination, oxidation, and C-C bond cleavage reactivity of 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxycytosine. J. Am. Chem. Soc. 135 (39):14593.
[4] Madugundu et al. (2014) Hydroxyl-radical-induced oxidation of 5-methylcytosine in isolated and cellular DNA. Nucleic Acids Res. 42 (11):7450.