For research use only!
Shipping: shipped at ambient temperature
Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.
Shelf Life: 24 months after date of delivery
Molecular Formula: C10H13N3O5
Molecular Weight: 255.23 g/mol
Exact Mass: 255.09 g/mol
Purity: ≥ 95 % (HPLC)
Form: white to off-white powder
Spectroscopic Properties: λmax 283 nm, ε 11.0 L mmol-1 cm-1 (Tris-HCl pH 7.5)
Use in epigenetic therapy
Metabolism of dC substituted at position 5[3,4]
 Schroeder (2014) Synthesis of a DNA promoter segment containing all four epigenetic nucleosides: 5-Methyl-, 5-hydroxymethyl-, 5-formyl-, and 5-carboxy-2'-deoxycytidine. Angew. Chem. Int. Ed. 53:315.
 Zauri et al. (2015) CDA directs metabolism of epigenetic nucleosides revealing a therapeutic window in cancer. Nature 524:114.
 Schiesser et al. (2013) Deamination, oxidation, and C-C bond cleavage reactivity of 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxycytosine. J. Am. Chem. Soc. 135 (39):14593.
 Madugundu et al. (2014) Hydroxyl-radical-induced oxidation of 5-methylcytosine in isolated and cellular DNA. Nucleic Acids Res. 42 (11):7450.