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Halogen-containing 2'-Deoxy-nucleosides

Halogenated nucleosides are suitable in a variety of structural studies.

Brom or Iod containing nucleosides are usefull in crystallography studies of oligonucleotide structure. Being photolabile, they apply as well in probing the structure of protein-DNA complexes for cross-linking studies.

Oligonucleotides, incorporating 2'-F-nucleoside residues, are widely employed in RNA and aptamer research. 2'-Fluoro-2'-deoxynucleoside-5'-triphosphates are popular products for various applications, such as PCR and DNA-, RNA-polymerase or reverse transcriptase based assays.