Halogenated nucleosides are suitable in a variety of structural studies.
Brom or Iod containing nucleosides are usefull in crystallography studies of oligonucleotide structure. Being photolabile, they apply as well in probing the structure of protein-DNA complexes for cross-linking studies.
Oligonucleotides, incorporating 2'-F-nucleoside residues, are widely employed in RNA and aptamer research. 2'-Fluoro-2'-deoxynucleoside-5'-triphosphates are popular products for various applications, such as PCR and DNA-, RNA-polymerase or reverse transcriptase based assays.