Standard and labile base protection in combination with Dimethoxytrityl (DMT)-protection of the 5'-Hydroxyl group.

nucleoside N-prot. DMT

R1: OH (ribo), H (deoxy)
R2: e.g. Acetyl (Ac), Benzyl (Bz), Dimethylformamidine (DMF), iso-Butylryl (iBu), Phenoxyacetyl (PAC) or Fluorenylmethoxycarbonyl (Fmoc)

Find as well further modifications at 2'- and 3'-position such as tert-Butyldimethylsilyl (TBDMS) or Methyl.

Browse the sections below to navigate our portfolio of base-protected and other nucleosides with 5'-DMT-protected sugar moiety: