8-Oxo-2'-deoxyguanosine (8-Oxo-dG), 25 mg pack

2-amino-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3, 7-dihydropurine-6,8-dione

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N-1045 25 mg 307,50 Add to Basket/Quote Add to Notepad

For research use only!

Shipping: shipped on blue ice

Storage Conditions: store at 4 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible. If stored as recommended, Jena Bioscience guarantees optimal performance of this product for 12 months after date of delivery.

Shelf Life: 12 months

Molecular Formula: C10H13N5O5

Molecular Weight: 283.24 g/mol

CAS#: 88847-89-6

Purity: > 98 %

Form: solid

Selected References:
Lee et al. (2010) Urine 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG), a specific marker of oxidative stress, using direct, isocratic LC-MS/MS: Method evaluation and application in study of biological variation in healthy adults. Clin Chim Acta 411 (5-6):416.
Sharma et al. (2004) Biological relevance of adduct detection to the chemoprevention of cancer. Clin Cancer Res 10 (15):4901.
Churchwell et al. (2002) Quantification of multiple DNA adducts formed through oxidative stress using liquid chromatography and electrospray tandem mass spectrometry. Chem Res Toxicol 15:1295.
Kai et al. (2002) An oxidized nucleotide affects DNA replication through activation of protein kinases in Xenopus egg lysates. Nucl. Acids Res. 30 (2):569.
Canitrot et al. (2000) Nucleotide excision repair DNA synthesis by excess DNA polymerase beta: a potential source of genetic instability in cancer cells. FASEB J. 14 (12):1765.
Nampalli et al. (2000) Efficient synthesis of 8-oxo-dGTP: A mutagenic nucleotide. Bioorg. Med. Chem. Lett. 10 (15):1677.