dUpNHp

(dUMPNP)

2'-Deoxyuridine-5'-[(α,β)-imido]diphosphate, Sodium salt

Product Cat. No. Amount Price (EUR) Buy / Note
S pack NU-902S 100 μl (10 mM) 118,44 Add to Basket/Quote Add to Notepad
L pack NU-902L 5 x 100 μl (10 mM) 346,94 Add to Basket/Quote Add to Notepad

For research use only!

Shipping: shipped on blue ice

Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible. If stored as recommended, Jena Bioscience guarantees optimal performance of this product for 12 months after date of delivery.

Shelf Life: 12 months

Molecular Formula: C9H15N3O10P2 (free acid)

Molecular Weight: 387.17 g/mol (free acid)

CAS#: 178809-71-7

Purity: ≥ 95 % (HPLC)

Form: clear aqueous solution, pH 7.5 ±0.5

Concentration: 10 mM - 11 mM

pH: 7.5 ±0.5

Spectroscopic Properties: λmax 262 nm; ε 10.2 L mmol-1 cm-1 (Tris-HCl pH 7.5)

Selected References:
Kovári et al. (2008) Methylene substitution at the a–b bridging position within the phosphate chain of dUDP profoundly perturbs ligand accommodation into the dUTPase active site. J. Biol. Chem. 71:308.
Barabás et al. (2004) Structural Insights into the Catalytic Mechanism of Phosphate Ester Hydrolysis by dUTPase. J. Biol. Chem. 279 (41):42907.
Persson et al. (1996) Synthesis of 2'-deoxyuridine 5'- (alpha,beta-imido)triphosphate: A substrate analogue and potent inhibitor of dUTPase. Bioorgan. Med. Chem. 4 (4):553.