2'-Deoxyuridine-5'-[(α,β)-imido]diphosphate, Sodium salt
For research use only!
Shipping: shipped on blue ice
Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.
Shelf Life: 12 months after date of delivery
Molecular Formula: C9H15N3O10P2 (free acid)
Molecular Weight: 387.17 g/mol (free acid)
Purity: ≥ 95 % (HPLC)
Form: clear aqueous solution, pH 7.5 ±0.5
Concentration: 10 mM - 11 mM
pH: 7.5 ±0.5
Spectroscopic Properties: λmax 262 nm; ε 10.2 L mmol-1 cm-1 (Tris-HCl pH 7.5)
Kovári et al. (2008) Methylene substitution at the ab bridging position within the phosphate chain of dUDP profoundly perturbs ligand accommodation into the dUTPase active site. J. Biol. Chem. 71:308.
Barabás et al. (2004) Structural Insights into the Catalytic Mechanism of Phosphate Ester Hydrolysis by dUTPase. J. Biol. Chem. 279 (41):42907.
Persson et al. (1996) Synthesis of 2'-deoxyuridine 5'- (alpha,beta-imido)triphosphate: A substrate analogue and potent inhibitor of dUTPase. Bioorgan. Med. Chem. 4 (4):553.