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XTP

Xanthosine-5'-triphosphate, Triethylammonium salt

Product Cat. No. Amount Price (EUR) Buy / Note
XTP NU-602S 15 μl (100 mM) 118,45 Add to Basket/Quote Add to Notepad
XTP NU-602L 5 x 15 μl (100 mM) 346,95 Add to Basket/Quote Add to Notepad

Structural formula of XTP

For research use only!

Shipping: shipped on blue ice

Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible. If stored as recommended, Jena Bioscience guarantees optimal performance of this product for 12 months after date of delivery.

Shelf Life: 12 months

Molecular Formula: C10H15N4O15P3 (free acid)

Molecular Weight: 524.16 g/mol (free acid)

CAS#: 6253-56-1

Purity: ≥ 95 % (HPLC)

Form: clear aqueous solution, pH 7.5 ±0.5

Concentration: 100 mM - 110 mM

pH: 7.5 ±0.5

Spectroscopic Properties: λmax 276 nm; ε 9.6 L mmol-1 cm-1 (Tris-HCl pH 7.5)

Applications:
Inhibitor of adenylyl and guanylyl cyclase[1]

Specific Ligands:

Soluble guanylyl cyclase[2]

Selected References:
[1] Spangler et al. (2011) Interaction of the diguanylate cyclase YdeH of Escherichia coli with 2', (3')-substituted purine and pyrimidine nucleotides. J. Pharmacol. Exp. Ther. 336 (1):234.
[2] Chang et al. (2005) Nitric Oxide-dependent Allosteric Inhibitory Role of a Second Nucleotide Binding Site in Soluble Guanylyl Cyclase. J. Biol. Chem. 280 (12):11513.
Beste et al. (2012) Nucleotidyl cyclase activity of soluble guanylyl cyclase α1β1. Biochemistry 51 (1):194.
Spangler et al. (2011) Interaction of the diguanylate cyclase YdeH of Escherichia coli with 2', (3')-substituted purine and pyrimidine nucleotides. J Pharmacol Exp. Ther. 336 (1):234.
Fulga et al. (2001) SR beta coordinates signal sequence release from SRP with ribosome binding to the translocon. EMBO J. 20 (9):2338.
Legate et al. (2000) Nucleotide-dependent binding of the GTPase domain of the signal recognition particle receptor betasubunit to the alpha-subunit. J. Biol. Chem. 275 (35):27439.
Sakash et al. (2000) The use of nucleotide analogs to evaluate the mechanism of the heterotropic response of Escherichia coli aspartate transcarbamoylase. Protein Sci. 9 (1):53.
Hwang et al. (1999) Structure-based identification of a novel NTPase from Methanococcus jannaschii. Nat. Struct. Biol. 6 (7):691.
Muraoka et al. (1999) Effects of purinenucleotide analogues on microtubule assembly. Cell Struct. Funct. 24 (5):305.
Seifert et al. (1999) Effects of guanine, inosine, and xanthine nucleotides on beta (2)-adrenergic receptor/G (s) interactions: Evidence for multiple receptor conformations. Mol. Pharmacol. 56 (2):348.
Yu et al. (1997) Characterization of a Go alpha mutant that binds xanthine nucleotides. J. Biol. Chem. 272 (29):18015.
Rybin et al. (1996) GTPase activity of Rab5 acts as a timer for endocytic membrane fusion. Nature 383 (6597):266.
Powers et al. (1995) Reciprocal stimulation of GTP hydrolysis by 2 directly interacting GTPases. Science 269 (5229):1422.