P1-(5'-Adenosyl) P4-(5'-uridyl) tetraphosphate, Sodium salt
For research use only!
Shipping: shipped on blue ice
Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.
Shelf Life: 12 months after date of delivery
Molecular Formula: C19H27N7O21P4 (free acid)
Molecular Weight: 813.35 g/mol (free acid)
Purity: ≥ 95 % (HPLC)
Form: clear aqueous solution
Concentration: 10 mM - 11 mM
pH: 7.5 ±0.5
Spectroscopic Properties: λmax 260 nm; ε 25.0 L mmol-1 cm-1 (Tris-HCl pH 7.5)
Synthesis by mutated enzyme H96G-Fhit
Formation by UTP-glucose-1-phosphate uridyltransferase
Synthesis by pyrococcus furiosus DNA ligase
Effector of Phosphotransferase
Inhibitor of Uridine Kinase
Vasoregulator through P2X1, P2Y2 and P2Y4 receptors
 Huang et al. (2004) Engineering human Fhit, a diadenosine triphosphate hydrolase, into an efficient dinucleoside polyphosphate synthase. J. Am. Chem. Soc. 126 (31):9548.
 Guranowski et al. (2004) Uridine 5'-polyphosphates (p4U and p5U) and uridine (5')polyphospho (5')nucleosides (Up (n)Ns) can be synthesized by UTP:glucose-1-phosphate uridylyltransferase from Saccharomyces cerevisiae. FEBS Lett. 561 (1-3):83.
 Günther et al. (2002) Thermostable Pyrococcus furiosus DNA lgase catalyzes the synthesis of (di)nucleoside polyphosphates. Extremophiles 6 (1):45.
 Marques et al. (1998) IMP-GMP 5'-nucleotidase from rat brain: activation by polyphosphates. J. Neurochem. 71 (3):1241.
 Cheng et al. (1986) Homogeneous uridine kinase from Ehrlich ascites tumor: substrate specificity and inhibition by bisubstrate analogs. Mol. Pharmacol. 30 (2):159.
 Jankowski et al. (2005) Uridine adenosine tetraphosphate: a novel endothelium- derived vasoconstrictive factor. Nature Medicine 11 (2):223.