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P1-(5'-Adenosyl) P6-(5'-adenosyl) hexaphosphate, Sodium salt

Product Cat. No. Amount Price (EUR) Buy / Note
AP6A NU-509S 20 μl (10 mM) 112,80 Add to Basket/Quote Add to Notepad
AP6A NU-509L 5 x 20 μl (10 mM) 330,42 Add to Basket/Quote Add to Notepad

Structural formula of AP6A

For research use only!

Shipping: shipped on blue ice

Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible. If stored as recommended, Jena Bioscience guarantees optimal performance of this product for 12 months after date of delivery.

Shelf Life: 12 months

Molecular Formula: C20H30N10O25P6 (free acid)

Molecular Weight: 996.35 g/mol (free acid)

CAS#: 56983-23-4

Purity: ≥ 95 % (HPLC)

Form: clear aqueous solution, pH 7.5 ±0.5

Concentration: 10 mM - 11 mM

pH: 7.5 ±0.5

Spectroscopic Properties: λmax 259 nm; ε 27.0 L mmol-1 cm-1 (Tris-HCl pH 7.5)

Kinetic parameters with arabidopsis thaliana Nudix hydrolase[1]
Action as neurotransmitter[2]
Modeling of binding to Nudix hydrolase Ndx1[3]
Mediated release of atrial atriopeptin (ANP)[4]

Specific Ligands:

Binding properties to Nudix hydrolase[5]

Selected References:
[1] Olejnik et al. (2007) Cloning and characterization of AtNUDT13, a novel mitochondrial Arabidopsis thaliana Nudix hydrolase specific for long-chain diadenosine polyphosphates. FEBS J. 274 (18):4877.
[2] Delicado et al. (2006) Dinucleoside polyphosphates and their interaction with other nucleotide signaling pathways. Pflugers Arch. 452 (5):563.
[3] Zheng et al. (2005)Homology modeling and substrate binding study of Nudix hydrolase Ndx1 from Thermos thermophilus HB8. Biochem. Biophys. Res. Commun. 333 (3):881.
[4] Yuan et al. (2007) Diadenosine tetraphosphate stimulates atrial ANP release via A (1) receptor: involvement of K (ATP) channel and PKC. Peptides 28 (7):1397.
[5] Garza et al. (2009) Kinetic, dynamic, ligand binding properties, and structural models of a dual-substrate specific nudix hydrolase from Schizosaccharomyces pombe. Biochemistry 48 (26):6224.
Gross et al. (2006) Nucleotide-binding domains of Cystic Fibrosis Transmembrane Conductance Regulator, an ABC Transporter, Catalyze Adenylate Kinase Activity but not ATP Hydrolysis. J. Biol. Chem. 281 (7):4058.
Luo et al. (1999) Identification of diadenosine hexaphosphate in human erythrocytes. Hypertension 34:872.
Van der Giet et al. (1999) Evidence for two different P2X-receptors mediating vasoconstriction of Ap5A and Ap6A in the isolated perfused rat kidney. Br. J. Pharmacol. 127:1463.
Fontes et al. (1999) Acyl-CoA synthetase catalyzes the synthesis of diadenosine hexaphosphate (Ap6A). Biochimie 81:229.
Schluter et al. (1994) Diadenosine phosphates and the physiological control of blood pressure. Nature 367:186.
Morii et al. (1992) Adenosine (5')hexaphospho (5')adenosine stimulation of a Ca (2+)-induced Ca (2+)-release channel from skeletal muscle sarcoplasmic reticulum. Eur. J. Biochem. 205:979.