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Stavudine monophosphate, Sodium Salt

2',3'-Didehydro-2',3'-dideoxythymidine-5'-monophosphate, Sodium salt

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NU-1603S 20 μl (10 mM) 112,80 Add to Basket/Quote Add to Notepad
Structural formula of d4TMP (Stavudine monophosphate, Sodium Salt, 2',3'-Didehydro-2',3'-dideoxythymidine-5'-monophosphate, Sodium salt)
Structural formula of d4TMP

For research use only!

Shipping: shipped on blue ice

Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.

Shelf Life: 12 months after date of delivery

Molecular Formula: C10H13N2O7P (free acid)

Molecular Weight: 304.19 g/mol (free acid)

CAS#: 3715-64-8

Purity: ≥ 95 % (HPLC)

Form: clear aqueous solution

Concentration: 10 mM - 11 mM

pH: 7.5 ±0.5

Spectroscopic Properties: λmax 266 nm; ε 10.1 L mmol-1 cm-1 (Tris-HCl pH 7.5)

Selected References:
Coulier et al. (2008) Simultaneous determination of endogenous deoxynucleotides and phosphorylated nucleoside reverse transcriptase inhibitors in peripheral blood mononuclear cells using ion-pair liquid chromatography coupled to mass spectrometry. Proteomics Clin. Appl. 2:1557.
De Clercq (2002) Highlights in the development of new antiviral agents. Mini Rev. Med. Chem. 2:163.
Mas et al. (2002) Multidrug-resistant HIV-1 reverse transcriptase: involvement of ribonucleotide-dependent phosphorolysis in cross-resistance to nucleoside analogue inhibitors. J. Mol. Biol. 267:181.
Selmi et al. (2001) The valine-to-threonine 75 substitution in human immunodeficiency virus type 1 reverse transcriptase and its relation with stavudine resistance. J. Biol. Chem. 276:13965.
Huang et al. (1992) Selective action of 2',3'-didehydro-2',3'-dideoxythymidine triphosphate on human immunodeficiency virus reverse transcriptase and human DNA polymerases. J. Biol. Chem. 267:2817.