» Sign in / Register

8-Bromo-GTP

(8Br-GTP)

8-Bromo-guanosine-5'-triphosphate, Sodium salt

Product Cat. No. Amount Price (EUR) Buy / Note
8-Bromo-GTP NU-118S 50 μl (10 mM) 118,45 Add to Basket/Quote Add to Notepad
8-Bromo-GTP NU-118L 5 x 50 μl (10 mM) 346,95 Add to Basket/Quote Add to Notepad

Structural formula of 8-Bromo-GTP

For research use only!

Shipping: shipped on blue ice

Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible. If stored as recommended, Jena Bioscience guarantees optimal performance of this product for 12 months after date of delivery.

Shelf Life: 12 months

Molecular Formula: C10H15N5O14P3Br (free acid)

Molecular Weight: 602.07 g/mol (free acid)

CAS#: 23197-98-0

Purity: ≥ 95 % (HPLC)

Form: clear aqueous solution, pH 7.5 ±0.5

Concentration: 10 mM - 11 mM

pH: 7.5 ±0.5

Spectroscopic Properties: λmax 259 nm; ε 14.0 L mmol-1 cm-1 (Tris-HCl pH 7.5)

Applications:
Inhibition of RNA triphosphatases[1]
Inhibition of GTP-hydrolases[2]
Conformational studies on syn-anti dynamics of GTP[3]

Specific Ligands:

Yeast RNA triphosphates[1]

Cytoskeletal protein FtsZ and tubulin[2, 4]

Selected References:
[1] Issur et al. (2009) Nucleotide analogs and molecular modeling studies reveal key interactions involved in substrate recognition by the yeast RNA triphosphatase. Nucleic Acid Res. 37:3714.
[2] Läppchen et al. (2005) GTP Analogue Inhibits Polymerization and GTPase Activity of the Bacterial Protein FtsZ without Affecting Its Eukaryotic Homologue Tubulin. Biochemistry 44 (21):7879.
[3] Hritz and Oostenbrink (2008) Hamiltonian replica exchange molecular dynamics using soft-core interactions. J. Chemical Phys. 128:144121/1.
[4] Laeppchen et al. (2008) Probing FtsZ and tubulin with C8-substituted GTP analogs reveals differences in their nucleotide binding sites. Chemistry and Biology 15:189.
Gilles Labesse et al. (2011) Structural and functional characterization of the Mycobacterium tuberculosis uridine monophosphate kinase: insights into the allosteric regulation. Nucleic Acids Res. 39 (8):3458.