8-Bromo-guanosine-5'-triphosphate, Sodium salt
For research use only!
Shipping: shipped on blue ice
Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.
Shelf Life: 12 months after date of delivery
Molecular Formula: C10H15N5O14P3Br (free acid)
Molecular Weight: 602.07 g/mol (free acid)
Purity: ≥ 95 % (HPLC)
Form: clear aqueous solution, pH 7.5 ±0.5
Concentration: 10 mM - 11 mM
pH: 7.5 ±0.5
Spectroscopic Properties: λmax 259 nm; ε 14.0 L mmol-1 cm-1 (Tris-HCl pH 7.5)
Inhibition of RNA triphosphatases
Inhibition of GTP-hydrolases
Conformational studies on syn-anti dynamics of GTP
Yeast RNA triphosphates
Cytoskeletal protein FtsZ and tubulin[2, 4]
 Issur et al. (2009) Nucleotide analogs and molecular modeling studies reveal key interactions involved in substrate recognition by the yeast RNA triphosphatase. Nucleic Acid Res. 37:3714.
 Läppchen et al. (2005) GTP Analogue Inhibits Polymerization and GTPase Activity of the Bacterial Protein FtsZ without Affecting Its Eukaryotic Homologue Tubulin. Biochemistry 44 (21):7879.
 Hritz and Oostenbrink (2008) Hamiltonian replica exchange molecular dynamics using soft-core interactions. J. Chemical Phys. 128:144121/1.
 Laeppchen et al. (2008) Probing FtsZ and tubulin with C8-substituted GTP analogs reveals differences in their nucleotide binding sites. Chemistry and Biology 15:189.
Gilles Labesse et al. (2011) Structural and functional characterization of the Mycobacterium tuberculosis uridine monophosphate kinase: insights into the allosteric regulation. Nucleic Acids Res. 39 (8):3458.