Cytarabine triphosphate, Sodium salt
Cytidine-arabinofuranoside-5'-triphosphate, Sodium salt
For research use only!
Shipping: shipped on blue ice
Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible. If stored as recommended, Jena Bioscience guarantees optimal performance of this product for 12 months after date of delivery.
Shelf Life: 12 months
Molecular Formula: C9H16N3O14P3 (free acid)
Molecular Weight: 483.15 g/mol (free acid)
Purity: ≥ 95 % (HPLC)
Form: clear aqueous solution, pH 7.5 ±0.5
Concentration: 10 mM - 11 mM
pH: 7.5 ±0.5
Spectroscopic Properties: λmax 271 nm; ε 8.9 L mmol-1 cm-1 (Tris-HCl pH 7.0)
Treatment of acute myeloid leukemia
Inhibition of DNA synthesis by incorporation
Detection with isocratic HPLC
Inhibition of DNA ligases and polymerases
 Negoro et al. (2011) Characterization of cytarabine-resistant leukemic cell lines established from five different blood cell lineages using gene expression and proteomic analyses. Int. J. Oncol. 38 (4):911.
 Yamauchi et al. (2009) Intracellular cytarabine triphosphate production correlates to deoxycytidine kinase/cytosolic 5'-nucleotidase II expression ratio in primary acute myeloid leukemia cells. Biochem. Pharmacol. 77 (12):1780.
 Nishi et al. (2006) A new, simple method for quantifying gemcitabine triphosphate in cancer cells using isocratic high-performance liquid chromatography. Cancer Sci. 97 (11):1274.
 Colón-Cesario et al. (2006) An inhibitor of DNA recombination blocks memory consolidation, but not reconsolidation, in context fear conditioning. J. Neurosci. 26 (20):5524.