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ara-Cytidine-5'-triphosphate (ara-CTP)

Cytarabine triphosphate, Sodium salt

Cytidine-arabinofuranoside-5'-triphosphate, Sodium salt

Product Cat. No. Amount Price (EUR) Buy / Note
ara-Cytidine-5'-triphosphate (ara-CTP) NU-1170S 100 μl (10 mM) 118,45 Add to Basket/Quote Add to Notepad
ara-Cytidine-5'-triphosphate (ara-CTP) NU-1170L 5 x 100 μl (10 mM) 346,95 Add to Basket/Quote Add to Notepad

Structural formula of ara-Cytidine-5'-triphosphate (ara-CTP)

For research use only!

Shipping: shipped on blue ice

Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible. If stored as recommended, Jena Bioscience guarantees optimal performance of this product for 12 months after date of delivery.

Shelf Life: 12 months

Molecular Formula: C9H16N3O14P3 (free acid)

Molecular Weight: 483.15 g/mol (free acid)

CAS#: 13191-15-6

Purity: ≥ 95 % (HPLC)

Form: clear aqueous solution, pH 7.5 ±0.5

Concentration: 10 mM - 11 mM

pH: 7.5 ±0.5

Spectroscopic Properties: λmax 271 nm; ε 8.9 L mmol-1 cm-1 (Tris-HCl pH 7.0)

Applications:
Treatment of acute myeloid leukemia[1]
Inhibition of DNA synthesis by incorporation[2]
Detection with isocratic HPLC[3]
Inhibition of DNA ligases and polymerases[4]

Selected References:
[1] Negoro et al. (2011) Characterization of cytarabine-resistant leukemic cell lines established from five different blood cell lineages using gene expression and proteomic analyses. Int. J. Oncol. 38 (4):911.
[2] Yamauchi et al. (2009) Intracellular cytarabine triphosphate production correlates to deoxycytidine kinase/cytosolic 5'-nucleotidase II expression ratio in primary acute myeloid leukemia cells. Biochem. Pharmacol. 77 (12):1780.
[3] Nishi et al. (2006) A new, simple method for quantifying gemcitabine triphosphate in cancer cells using isocratic high-performance liquid chromatography. Cancer Sci. 97 (11):1274.
[4] Colón-Cesario et al. (2006) An inhibitor of DNA recombination blocks memory consolidation, but not reconsolidation, in context fear conditioning. J. Neurosci. 26 (20):5524.