6-Methylthioinosine-5'-monophosphate, Triethylammonium salt
For research use only!
Shipping: shipped on blue ice
Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.
Shelf Life: 12 months after date of delivery
Molecular Formula: C11H15N4O7PS (free acid)
Molecular Weight: 378.29 g/mol (free acid)
Purity: ≥ 95 % (HPLC)
Form: clear aqueous solution
Concentration: 10 mM - 11 mM
pH: 7.5 ±0.5
Spectroscopic Properties: λmax 224/292 nm; ε 11.5/19.0 L mmol-1 cm-1 (Tris-HCl pH 7.5)
Catabolism by purine-5'-nucleotidase
Transport by multidrug resistance proteins MRP4 and MRP5
Strong inhibitor of purine synthesis de novo
 Brouwer et al. (2005) Role of 5'-nucleotidase in thiopurine metabolism:Enzyme kinetic profile and association with thio-GMP levels in patients with acute lymphoblastic leukemia during 6-mercaptopurine treatment. Clinica Chemica Acta 361:95.
 Wielinga et al. (2002) Thiopurine metabolism and identification of the thiopurine metabolites transported by MRP4 and MRP5 overexpressed in human embryonic kidney cells. Molecular Pharmacology 62:1321.
 Stet et al. (1994) Decrease of S-adenosylmethionine synthesis by 6-mercaptopurine ribonucleoside in Molt F4 human malignant lymphoblasts. Biochemical J. 304:163.
Lavi et al. (1985) A rapid and sensitive high-performance liquid chromatographic assay for 6-mercaptopurine metabolites in red blood cells. Anal. Biochem. 144 (2):514.