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6-Methylthio-IMP

6-Methylthioinosine-5'-monophosphate, Triethylammonium salt

6-Methylmercapto-9-(β-D-ribofuranosyl)purine-5'-monophosphate

Product Cat. No. Amount Price (EUR) Buy / Note
6-Methylthio-IMP NU-1131S 150 μl (10 mM) 112,80 Add to Basket/Quote Add to Notepad
6-Methylthio-IMP NU-1131L 5 x 150 μl (10 mM) 330,42 Add to Basket/Quote Add to Notepad

Structural formula of 6-Methylthio-IMP

For research use only!

Shipping: shipped on blue ice

Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible. If stored as recommended, Jena Bioscience guarantees optimal performance of this product for 12 months after date of delivery.

Shelf Life: 12 months

Molecular Formula: C11H15N4O7PS (free acid)

Molecular Weight: 378.29 g/mol (free acid)

CAS#: 7021-52-5

Purity: ≥ 95 % (HPLC)

Form: clear aqueous solution, pH 7.5 ±0.5

Concentration: 10 mM - 11 mM

pH: 7.5 ±0.5

Spectroscopic Properties: λmax 224/292 nm; ε 11.5/19.0 L mmol-1 cm-1 (Tris-HCl pH 7.5)

Applications:
Catabolism by purine-5'-nucleotidase[1]
Transport by multidrug resistance proteins MRP4 and MRP5[2]
Strong inhibitor of purine synthesis de novo[3]

Selected References:
[1] Brouwer et al. (2005) Role of 5'-nucleotidase in thiopurine metabolism:Enzyme kinetic profile and association with thio-GMP levels in patients with acute lymphoblastic leukemia during 6-mercaptopurine treatment. Clinica Chemica Acta 361:95.
[2] Wielinga et al. (2002) Thiopurine metabolism and identification of the thiopurine metabolites transported by MRP4 and MRP5 overexpressed in human embryonic kidney cells. Molecular Pharmacology 62:1321.
[3] Stet et al. (1994) Decrease of S-adenosylmethionine synthesis by 6-mercaptopurine ribonucleoside in Molt F4 human malignant lymphoblasts. Biochemical J. 304:163.
Lavi et al. (1985) A rapid and sensitive high-performance liquid chromatographic assay for 6-mercaptopurine metabolites in red blood cells. Anal. Biochem. 144 (2):514.