ara-Adenosine-5'-triphosphate (ara-ATP)

Vidarabine triphosphate, Sodium Salt

Adenine-arabinofuranoside-5'-triphosphate, Sodium salt

Product Cat. No. Amount Price (EUR) Buy / Note
S pack NU-1111S 50 μl (10 mM) 112,80 Add to Basket/Quote Add to Notepad
L pack NU-1111L 5 x 50 μl (10 mM) 330,42 Add to Basket/Quote Add to Notepad

For research use only!

Shipping: shipped on blue ice

Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible. If stored as recommended, Jena Bioscience guarantees optimal performance of this product for 12 months after date of delivery.

Shelf Life: 12 months

Molecular Formula: C10H16N5O13P3 (free acid)

Molecular Weight: 507.18 g/mol (free acid)

CAS#: 3714-60-1

Purity: ≥ 95 % (HPLC)

Form: clear aqueous solution, pH 7.5 ±0.5

Concentration: 10 mM - 11 mM

pH: 7.5 ±0.5

Spectroscopic Properties: λmax 259 nm; ε 15.3 L mmol-1 cm-1 (Tris-HCl pH 7.5)

Applications:
Isolation from marine sponge Tethya crypta[1]
Antiviral properties[2]
Substrate for poly(A) polymerase (gammaPAP)[3]

Selected References:
[1] Sagar et al. (2010) Antiviral lead compounds from marine sponges. Mar. Drugs. 8 (10):2619.
[2] Wilhelmus (2010) Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis. Cochrane Database Syst Rev. (12):CD002898.
[3] Chen et al. (2008) Polyadenylation inhibition by the triphosphates of deoxyadenosine analogues. Leuk. Res. 32 (10):1573.
Genini et al. (2000) Nucleotide requirements for the in vitro activation of the apoptosis protein-activating factor-1-mediated caspase pathway. J. Biol. Chem. 275 (1):29.
Ghoshal et al. (1991) Ara-ATP impairs 3'-end processing of pre-messenger-RNAs by inhibiting both cleavage and polyadenylation. Nucleic Acids Res. 19 (21):5871.
Biron et al. (1991) Selective anabolism of 6-methoxypurine arabinoside in Varicella-zoster virus-infected cells. Antimicrob. Agents Ch. 35 (10):2116.
Demiranda et al. (1991) Anabolic pathway of 6-methoxypurine arabinoside in cells infected with Varicella-zoster virus. Antimicrob. Agents Ch. 35 (10):2121.
Plunkett et al. (1981) Cellular concentrations of dATP and ara-ATP in peripheral-blood leukemic-cells (PBC) and erythrocytes (RBC) from patients treated with deoxycoformycin (DCF) or Arabinosyladenine (ara-A). P. Am. Assoc. Canc. Res. 22 (Mar):177.
Shewach et al. (1981) Relationship between ara-ATP concentration, DNA synthetic capacity (DSC) and viability in cho cells. P. Am. Assoc. Canc. Res. 22 (Mar):255.
Spater et al. (1981) Neuronal phosphatase-activities with ara-AMP and ara-ATP as substrates. J. Histochem. Cytochem. 29 (6):693.
Chanda et al. (1980) Inhibition of vesicular stomatitis-virus transcriptase invitro by phosphonoformate and ara-ATP. Virology 107 (2):562.
Dennis et al. (1980) RNA-polymerase - potent linear competitive-inhibition by D Arabinose-5-triphosphate compared to non-inhibition by 5' ara-ATP. Biochem. Bioph. Res. Co. 94 (1):205.
Shewach et al. (1979) Effect of deoxycoformycin (DCF) on the toxicity and metabolism of 9-beta-d-arabinofuranosyladenine (ara-A) and its 5'-triphosphate (ara-ATP) in cho cells. P. Am. Assoc. Canc. Res. 20 (Mar):183.
Chanda et al. (1979) Inhibition of invitro RNA-transcription of vesicular stomatitis-virus by phosphonoformate and ara-ATP. Fed. Proc. 38 (3):814.
Rose et al. (1978) Selective-inhibition of RNA polyadenylation by ara-ATP invitro - possible mechanism for anti-viral action of ara-A. Biochem. Bioph. Res. Co. 81 (4):1418.
Ortiz (1972) Inhibition of escherichia-coli adenyl-cyclase by ara ATP. Biochem. Bioph. Res. Co. 46 (4):1728.