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Ribavirin-triphosphate

Sodium Salt

1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide-5'-triphosphate, Sodium salt

Product Cat. No. Amount Price (EUR) Buy / Note
Ribavirin-triphosphate NU-1105S 20 μl (10 mM) 118,45 Add to Basket/Quote Add to Notepad
Ribavirin-triphosphate NU-1105L 5 x 20 μl (10 mM) 346,95 Add to Basket/Quote Add to Notepad

Structural formula of Ribavirin-triphosphate

For research use only!

Shipping: shipped on blue ice

Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible. If stored as recommended, Jena Bioscience guarantees optimal performance of this product for 12 months after date of delivery.

Shelf Life: 12 months

Molecular Formula: C8H15N4O14P3 (free acid)

Molecular Weight: 484.14 g/mol (free acid)

CAS#: 63142-71-2

Purity: ≥ 95 % (HPLC)

Form: clear aqueous solution, pH 7.5 ±0.5

Concentration: 10 mM - 11 mM

pH: 7.5 ±0.5

Spectroscopic Properties: λmax 230 nm; ε 3.6 L mmol-1 cm-1 (Tris-HCl pH 7.5)

Selected References:
Kiso et al. (2010) T-705 (favipiravir) activity against lethal H5N1 influenza A viruses. Proc. Natl. Acad. Sci. USA. 107 (2):882.
Maag et al. (2001) Hepatitis C virus RNA-dependent RNA polymerase (NS5B) as a mediator of the antiviral activity of ribavirin. J. Biol. Chem. 276 (49):46094.
Lanford et al. (2001) Ribavirin induces error-prone replication of GB virus B in primary tamarin hepatocytes. J. Virol. 75 (17):8074.
Crotty et al. (2000) The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen. Nat. Med. 6 (12):1375.
Ulrich et al. (2000) Towards the engineering of an orthogonal protein kinase/nucleotide triphosphate pair. Tetrahedron 56 (48):9495.
Hong et al. (1999) Direct antiviral activity of ribavirin: Hepatitis C virus NS5B polymerase incorporates ribavirin triphosphate into nascent RNA products. Hepatology 30 (4):773 Part 2 Suppl. S.
Jarvis et al. (1998) Ribavirin uptake by human erythrocytes and the involvement of nitrobenzylthioinosine-sensitive (es)- nucleoside transporters. Brit. J. Pharmacol. 123 (8):1587.
Hosoya et al. (1993) Comparative inhibitory effects of various nucleoside and nonnucleoside analogs on replication of influenza-virus type-A and type-B in-vitro and inovo. J. Infect. Dis. 168 (3):641.
Wray et al. (1985) Effect of ribavirin triphosphate on primer generation and elongation during influenza-virus transcription invitro. Antivir. Res. 5 (1):39.
Eriksson et al. (1977) Inhibition of influenza-virus ribonucleic-acid polymerase by ribavirin triphosphate. Antimicrob. Agents Ch. 11 (6):946.