Uridine 5'-triphosphate, Trisodium salt trihydrate
For research use only!
Shipping: shipped on blue ice
Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.
Shelf Life: 12 months after date of delivery
Molecular Formula: C9H12N2Na3O15P3 * 3H2O
Molecular Weight: 604.12 g/mol
Purity: > 90 % (HPLC)
Spectroscopic Properties: λmax 262 nm; ε 9.8 L mmol-1 cm-1 (Tris-HCl pH 7.0)
Activation of purinergic receptors[1,2,3,4]
Cardioprotection against hypoxic damage
Enzyme kinetic parameters
Phosphorylation of EGF-receptor vie purinergic receptors
Stimulation of neurogenesis and dopaminergic neurons
Enterovirus 71 3D RNA polymerase
Ligand for purinergic receptors:
Quality Control Specifications: in vitro transcription (T7 RNA polymerase): visible RNA fragments after 5 min incubation; DNases, RNases, Nicking Activity: not detectable; Proteases: not detectable
 Raqeeb et al. (2011) Purinergic P2Y2 receptors mediate rapid Ca2+ mobilization, membrane hyperpolarization and nitric oxide production in human vascular endothelial cells. Cell Calcium 49:240.
 Golan et al. (2011) Extracellular nucleotide derivatives protect cardiomyocytes against hypoxic stress. Biochemical Pharmacology 81:1219.
 Boucher et al. (2011) Distinct activation of epidermal growth factor receptor by UTP contributes to epithelial cell wound repair. American Journal Pathology 178:1092.
 Sugihara et al. (2011) Dual signaling pathway of arterial constriction by extracellular uridine-5-triphosphate in the rat. J. Pharmacological Sciences (Japan) 115:293.
 Ma et al. (2011) Molecular cloning and analysis of the UDP-glucose pyrophosphorylase in Streptococcus equi subsp. Zooepidemicus. Molecular Biology Reports 38:2751.
 Delic et al. (2011) Nucleotides affect neurogenesis and dopaminergic differentiation of mouse fetal midbrain-derived neural precursor cells. Puronergic Signalling 6:417.
 Jiang et al. (2011) Biochemical characterization of enterovirus 71 3D RNA polymerase. Biochim. Biophys. Acta, Gene Regulatory Mechanisms 1809:211.
 Pendergast et al. (2001) Synthesis and P2Y receptor activity of a series of uridine dinucleoside 5'-polyphosphates. Bioorg. Med. Chem. Lett. 11 (2):157.
 Shaver et al. (1997) 4-substituted uridine 5'-triphosphates as agonists of the P2Y2 purinergic receptor. Nucleosides and Nucleotides 16 (7):1099.
 Kim et al. (2002) Methanocarba modification of uracil and adenine nucleotides: High potency of northern ring conformation at P2Y1, P2Y2, P2Y4 and P2Y11 but not P2Y6 receptors. J. Med. Chem. 45:208.
 Nguyen et al. (1995) Cloning, expression, and chromosomal localization of human uridine nucleotide receptors. J. Biol. Chem. 270 (52):30845.