CTP - solution

100 mM

Cytidine 5'-triphosphate, Sodium salt

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pack NU-1011 1 ml (100 μmol) 27,58 Add to Basket/Quote Add to Notepad

For in vitro use only!

Shipping: shipped on blue ice

Storage Conditions: store at -20 °C

Shelf Life: 12 months

Molecular Formula: C9H16N3O14P3 (free acid)

Molecular Weight: 483.16 g/mol (free acid)

CAS#: 36051-68-0

EC number: 252-849-3

Purity: > 99 % (HPLC)

Form: clear aqueous solution, pH 8.0 ±0.2 (4 °C)

Concentration: 100 mM ±2 %

pH: 8.0 ±0.2

Spectroscopic Properties: λmax 271 nm; ε 8.9 L mmol-1 cm-1 (Tris-HCl pH 7.0)

Description:
Ultrapure CTP supplied as clear aqueous solution (pH 8.0).

Applications:
Physiological role in coronary artery disease[1]
Physiolocal role in lipid metabolism[2]
Physiological role in farnesol induced apoptosis[3]

Specific Ligands:

CTP synthase[4]

Phosphocholine cytidyltransferase alpha[2]

Ligand for purinergic receptors:
P2Y6[5]
P2X3[6]

Quality Control Specifications: in vitro transcription: suitable; contamination with bacterial and human DNA: not detectable; activity of DNase, Protease or Phosphatase: not detectable

Selected References:
[1] Lui et al. (2010) Evaluation of CT perfusion in setting of cerebral ischemia:patterns and pitfalls. American Journal of Neuroradiology 31:1552.
[2] Luoma (2010) Gene activation regresses artheriosclerosis, promotes health, and enhances longevity. Lipids in health and disease 9:67.
[3] Joo et al. (2010) Molecular mechanisms involved in farnesol-induced apotosis. Cancer letters 287:123.
[4] Cabeen et al. (2010) A metabolic assembly line in bacteria. Nature Cell Biology 12:731.
[5]Jayasekara et al. (2013) 4-Alkoxyimino-cytosine nucleotides: tethering approaches to molecular probes for the P2Y6 receptor. MedChemComm. 4 (8):1156.
[6]Garzia-Guzman et al. (1997) Molecular characterization and pharmacological properties of the human P2X3 purinoreceptor. Mol. Brain Res. 47 (1):59.
Spangler et al. (2011) Interaction of the diguanylate cyclase YdeH of Escherichia coli with 2', (3')-substituted purine and pyrimidine nucleotides. J. Pharmacol. Exp. Ther. 336 (1):234.