Jena Bioscience News Blog
Sep 25, 2026
Featured Article - September 2026: New RNA synthesis routes
"Primer- and template- independent RNA polymerization by terminal nucleotidyltransferase TENT4B" by Nagpal et al. (Nucleic Acids Research, Sep 23, 2026) is our featured scientific article for September. Read why we chose it!
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Aug 21, 2026
Featured Article - August 2026: Enhancing synthetic mRNA translation
"N4-Acetylcytidine enhances synthetic mRNA translation yield and fidelity." by Schiffers et al. (Nature, Jul 01, 2026) is our featured scientific article for August. Read what they found out!
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May 27, 2026
Optimized HighYield T7 RNA Labeling Kit configuration for enhanced flexibility
Our HighYield T7 RNA Labeling Kits have been extended with an additional reaction buffer for enhanced assay set-up flexibility. Read more...
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Feb 26, 2026
Featured Article - February 2026
"AquIRE reveals the mechanisms of clinically induced RNA damage and the conversation and dynamics of glycoRNAs." by Zhang et al. (Nucleic Acid Research, Feb 27, 2026) is our featured scientific article for February. Read the full story!
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Nov 10, 2025
tCOTP: Enhancing mRNA Studies with native-like Fluorescent Labels
Discover how tCOTP is transforming RNA research and opens new possibilities for tracking mRNA delivery and function. Read more...
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Jul 04, 2025
Now available: Cap analog m7GP32'-OmA
We extended our portfolio of RNA Cap Analogs: m7GP32'-OmA
Jun 24, 2025
Optimize in vitro transcription reactions: A modified T7 RNA Polymerase with reduced dsRNA formation
Double-stranded RNA (dsRNA) is a critical by-product of wildtype T7 RNA Polymerase-based in vitro transcription. It needs to be minimized in final RNA preparations to reduce the risk of undesired immune responses.
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May 15, 2025
dsRNA Antibodies: Powerful Tools for Research & Quality Control
Double-stranded RNA (dsRNA) antibodies are efficient tools for the detection of dsRNA in various samples.
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Mar 18, 2025
Improve lncRNA-protein pull-down experiments with Desthiobiotinylated RNA probes
We now offer Desthiobiotin-modified NTPs and Labeling Kits for efficient enzymatic preparation of Desthiobiotinylated long non-coding RNA (lncRNA) probes. Read more...
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Jul 31, 2024
5-Methylcytidine modification increases self-amplifying RNA effectiveness
Katalin Karikó‘s and Drew Weissman‘s Nobel Prize-winning concept of nucleoside base modifications as basis for the development of effective mRNA vaccines has been successfully applied to self-amplifying RNA (saRNA). Read more...
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Nov 02, 2023
Increase synthetic mRNA functionality with nucleoside base modifications
5’-capping and nucleoside base modifications significantly increase translation efficiency while reducing immunogenicity of synthetic mRNA. Read more...
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Mar 23, 2023
Efficient RNA Labeling with abberior® STAR dyes
Efficient preparation of abberior® STAR dye-labeled RNA is now easily achievable via in vitro transcription. Read more...
read moreMar 18, 2023
Now available: abberior® dye-labeled nucleotides
Select one of our catalog products UTP labeled with abberior® STAR RED dUTP labeled with abberior® STAR RED or contact us if you are interested in a different abberior® dye-nucleotide conjugate.
Jan 25, 2023
N1-Methylpseudouridine: Increase mRNA vaccine effectiveness
Evidence suggests that N1-Methylpseudouridine modification increases mRNA vaccine effectiveness. Read more... Research suggests that incorporation of N1-Methylpseudouridine increases mRNA vaccine effectiveness through enhanced protein expression combined with low immunogenicity. Read more...
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Nov 22, 2022
mRNA quality control: Easy detection of dsRNA impurities
Double-stranded RNA (dsRNA) is a major impurity of therapeutic mRNA produced by in vitro transcription. Impurity levels of this transcriptional by-product need to be tightly monitored in mRNA production lots to ensure efficient mRNA expression and to reduce the risk of undesired high immunogenicity.
read moreApr 14, 2022
AZDye-labeled CTPs available
We extended our portfolio of fluorescent nucleotides for in vitro transcription experiments with AZDye-labeled CTPs: CTP-PEG5-AZDye 488 CTP-PEG5-AZDye 555 CTP-PEG5-AZDye 594 CTP-PEG5-AZDye 647
Sep 21, 2021
Phosphorothioate-modified (m)RNA: Improved stability & enhanced translation efficiency
Phosphorothioate-modified (m)RNA is conveniently prepared by enzymatic incorporation of NTPαS thus generating (m)RNA with improved stability and translation efficiency profile. Read more...
read moreDec 08, 2020
Efficient enzymatic preparation of 2'F-modified Aptamers
RNA synthesis kits with a T7 RNA polymerase triple mutant are now available for efficient 2'F-modified Aptamers preparation: 2'F-dUTP-based, 2'F-dCTP-based, 2'F-dGTP-based, 2'F-dATP-based
Nov 03, 2020
Efficient dsRNA synthesis for RNAi applications
Double-stranded RNA (dsRNA) is a key molecule in RNA interference (RNAi)-mediated gene silencing at the mRNA level. Large amounts of dsRNA can be efficiently synthesized via in vitro transcription.
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Oct 06, 2020
Increase 5' homogeneity of in vitro transcribed RNA
Structural investigations of RNA require a homogenous RNA preparation. Learn how to reduce in vitro transcription-caused 5' heterogeneity!
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Sep 09, 2020
RNA-Protein Photocrosslinking: Site- and sequence-specific Tracking
Explore the advantages of using 4-Thio-uridine containing products to identify RNA-protein interactions both in cells and in vitro!
read moreJun 16, 2020
New: HighYield T7 RNAi Kit
HighYield T7 RNAi Kit is now available for the production of dsRNA >200 bp that can subsequently be used for RNA interference (RNAi) applications.
Jun 11, 2020
Poly (A) carrier RNA: Improved viral RNA recovery
Poly (A) carrier RNA facilitates quantitative purification of low RNA amounts. Read more...
read moreJun 09, 2020
New: Highly concentrated T7 RNA Polymerase version
T7 RNA Polymerase (HC) is now available for set-up and optimization of individual high yield in vitro transcription reactions.
Jun 06, 2020
Now available: Poly(A) carrier RNA
We now offer Poly(A) carrier RNA for quantitative purification of RNA and DNA.
Apr 08, 2020
Efficient RNA Labeling with AZDyes (structural analogs of Alexa Fluor® dyes)
Efficient preparation of AZDye-labeled RNA is now easily achievable via in vitro transcription. Read more...
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Apr 03, 2020
The gold standard in viral dsRNA detection: Monoclonal J2, K1 & K2 antibodies
Anti-dsRNA monoclonal antibodies are efficient tools for the detection of dsRNA both in cell culture and FFPE samples. Read more...
read moreMar 26, 2020
Monoclonal antibodies for (viral) dsRNA detection
We now offer the Anti-dsRNA monoclonal antibodies J2, K1 and K2.
Mar 20, 2020
AZDye (structural analogs of Alexa Fluor® Dyes) RNA Labeling Kits
Efficient AZDye RNA labeling is now feasible with our HighYield T7 AZDye 488-, HighYield T7 AZDye 555-, HighYield T7 AZDye 594- and HighYield T7 AZDye 647-RNA Labeling Kits.
Feb 24, 2020
New: HighYield T7 P&L RNA Synthesis Kit
We now offer a HighYield RNA Synthesis Kit based on a modified T7 RNA Polymerase that has been associated with decreased abortive transcription, increased transcript 5' homogeneity and increased 5' incorporation efficiency of GTP analogs.
Feb 06, 2020
Modified mRNA synthesis beyond the classics
5’-capping and epigenetic nucleotide modifications are critical for efficient translation and reduced immunogenicity of synthetic mRNA. The classic combination of modifications consists of ARCA, 5-methylcytidine and pseudouridine. Promising extensions of the mRNA modification toolbox are available.
read moreJan 24, 2020
IR dye - labeled DNA Probes
We now offer ATTO680 NT Labeling kit for the preparation of ATTO680-labeled DNA probes via nick translation.
Nov 05, 2019
Northern Blots: 0.05 fmol detection limit with near-IR RNA Probes
Current near-IR fluorescent RNA probes use dye-labeled nucleotides with only moderate sensitivity. Use copper-free CLICK labeling for increased sensitivity. Learn more here!
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Oct 01, 2019
CRISPR/Cas: RNA-guided gene targeting
CRISPR/Cas systems are the most flexible and efficient site-directed gene targeting tools currently available. Learn more!
read moreSep 30, 2019
SpCas9-specific sgRNA Synthesis
We now offer a convenient and efficient HighYield T7 sgRNA Synthesis Kit (SpCas9) for cloning-free preparation of SpCas9-specific sgRNA. Individual (s)gRNA-encoding T7 DNA templates (e.g with a different Cas9 scaffold or for different Cas endonucleases) can efficiently be in vitro transcribed with the HighYield T7 RNA Synthesis Kit.
Sep 11, 2019
3'-End RNA-modifying enzymes
We now offer the RNA-modifying enzyme Yeast Poly(A) Polymerase.
Aug 19, 2019
Interested in ARCA-capped and internally modified RNA?
We now offer HighYield kits for synthesis of ARCA-capped and/or 5-methylcytosine & pseudouridine-modified (m)RNA.
Jun 25, 2019
New HighYield T7 RNA Labeling Kits
HighYield T7 RNA Labeling Kits for preparation of Digoxigenin, Biotin and fluorescent RNA probes are now available. The single nucleotide format offers maximum optimization flexibility.
Jun 07, 2019
HighYield T7 RNA Synthesis Kit
Now available! Our HighYield T7 RNA Synthesis Kit is designed for the efficient production of unmodified and modified RNA.
Mar 07, 2019
New Section: RNA Technologies
Looking for products to support your RNA research? Then have a look here!
read moreFeb 18, 2019
New Section: RNA Technologies
Looking for products to support your RNA research? Have a look at our new RNA Technologies section. Our product portfolio will constantly be extended. Want to stay updated? Sign up for our RNATech newsletter or contact us at rnatech@jenabioscience.com!
