Jena Bioscience News Blog
Sep 25, 2026
Featured Article - September 2026: New RNA synthesis routes
"Primer- and template- independent RNA polymerization by terminal nucleotidyltransferase TENT4B" by Nagpal et al. (Nucleic Acids Research, Sep 23, 2026) is our featured scientific article for September. Read why we chose it!
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Aug 21, 2026
Featured Article - August 2026: Enhancing synthetic mRNA translation
"N4-Acetylcytidine enhances synthetic mRNA translation yield and fidelity." by Schiffers et al. (Nature, Jul 01, 2026) is our featured scientific article for August. Read what they found out!
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Jul 09, 2026
Featured Article - July 2026: Genome stability during replication
"Replication-Stress-Induced Chromatin Loops Protect Fork Stability." by Gaggioli et al. (Nature, Jul 01, 2026) is our featured scientific article for July. Read why it matters!
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Jul 07, 2026
Fission impossible: Non-hydrolyzable nucleotide analogs
More than twenty years of expertise in synthesizing non-hydrolyzable nucleotides led to a comprehensive product portfolio. Read more...
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Jun 23, 2026
Find the perfect match: Nucleotide selectors for RNA & DNA labeling
Quickly explore our portfolio of modified nucleotides and associated kits to find the perfect match for your DNA or RNA labeling application. Learn how it works!
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Jun 18, 2026
Extended CLICK nucleotide portfolio
Both 5-Ethynyl-dCTP and 5'-Azidohexyl-pApG are now available as catalog products.
Apr 28, 2026
Featured Article - April 2026
"A single viral enzyme drives tRNA-dependent DNA hypermodification." by Silva et al. (Nature Communications, Apr 03, 2026) is our featured scientific article for April. Read more here!
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Apr 16, 2026
High sensitivity & low background detection: Digoxigenin-labeled DNA & RNA probes
Explore our toolbox for enzymatic Digoxigenin labeling of DNA and RNA probes. Read more...
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Mar 20, 2026
Featured Article - March 2026
"Allosteric targeting with antiviral nucleotide analogs allows fine tuning of SAMHD1 dNTPase activity." by Dirks et al. (Journal of Biological Chemistry, Jan 29, 2026) is our featured scientific article for March. Read the full story!
read moreMar 13, 2026
Now available: DIG-11-dCTP
We extended our portfolio of Digoxigenin-modified nucleotides with DIG-11-dCTP.
Mar 04, 2026
5’-Azido-puromycin: Copper-free CLICK labeling of newly synthesized proteins
5’-Azido-puromycin allows visualization of newly synthesized proteins via copper-free CLICK labeling. Read more...
read moreFeb 19, 2026
New cap analog m7GP3N6-AH-BioA
We extended our m7GpppA-N6-aminohexyl-Biotin (m7GP3N6-AH-BioA).
Feb 13, 2026
Extended CLICK nucleotide portfolio:
2'-Azido-2'-dGTP and 5-Ethynyl-CTP are now available as catalog products. Check out our complete portfolio of CLICK-functionalized nucleotides as well: Azide-functionalized nucleotides Alkyne-functionalized nucleotides DBCO-functionalized nucleotides
Jan 06, 2026
Reversibly 3'-O-blocked (d)NTPs: Building blocks for controlled, stepwise DNA & RNA synthesis
Explore our toolbox of reversible 3’-O-blocked nucleotides beyond their application in short-read sequencing-by synthesis-methods (SBS).
read moreDec 18, 2025
Now available: Thienoguanosine
We now offer Thienoguanosine, a fluorescent isomorphic guanosine analog, ideal for 5´-end RNA labeling via in vitro transcription.
Dec 09, 2025
Expanding the bacterial nucleotide second messenger vocabulary
An expanding repertoire of linear and cyclic bacterial nucleotide second messengers has been discovered during the past years. Read more...
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Nov 21, 2025
Featured Article - November 2025
"The Panoptes system uses decoy cyclic nucleotides to defend against phage." - by Sullivan et al. (Nature, Oct 01, 2025) is our featured scientific article for November. Read the full story!
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Nov 10, 2025
tCOTP: Enhancing mRNA Studies with native-like Fluorescent Labels
Discover how tCOTP is transforming RNA research and opens new possibilities for tracking mRNA delivery and function. Read more...
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Oct 22, 2025
Extended portfolio of fluorescently labeled ATPs
Our newly developed, linker-optimized fluorescent 7-Deaza-ATPs are now available as excellent substrates for T7 RNA Polymerase-mediated in vitro transcription. Read more...
read moreOct 15, 2025
New: 5-Formyl-dCTP and 5-Carboxy-dCTP
Our portfolio of epigenetically relevant pyrimidines has been complemented by 5-Formyl-dCTP and 5-Carboxy-dCTP.
Oct 14, 2025
Now available: ppApp and pppApp
We extended our portfolio with the alarmones Adenosine-3‘-diphosphate-5‘-diphosphate (ppApp) and Adenosine-3‘-diphosphate-5‘-triphosphate (pppApp). Check out our complete portfolio of nucleoside polyphosphates (pnNpn) as well!
Oct 08, 2025
Featured Article - October 2025
"Replisome passage through the cohesin ring." - by Glaser et al. (Cell, Sep 16, 2025) is our featured scientific article for October. Find out more about it!
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Sep 26, 2025
SNP genotyping by mass spectrometry using mass-modified nucleotides
Mass-modified nucleotides allow unambiguous allele discrimination in mass spectrometry-based genotyping of single nucleotide polymorphisms (SNPs). Read more...
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Sep 15, 2025
Featured Article - September 2025
"FEN1 is critical for rapid single-strand break repair in G1 phase" - by Burdova et al. (Nucleic Acids Research, Aug 12, 2025) is our featured scientific article for September. Read why it matters!
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Sep 05, 2025
Sequencing-by-synthesis: Fluorescent reversible 3’-O-blocked dNTPs
Fluorescent reversible 3’-O-blocked dNTPs are key components of short read sequencing technologies such as reversible termination sequencing-by-synthesis (SBS). Read more...
read moreAug 14, 2025
Acyclo-NTPs for SNP genotyping
In addition to ddNTPs, we now offer Acyclo-NTPs (Acyclo-ATP, Acyclo-CTP, Acyclo-GTP, Acyclo-5-Br-UTP) for mass spectrometry-based SNP genotyping.
Aug 11, 2025
Now available: Fluorescent phosphate-modified AMPs
Check out our α-[(6-Aminohexyl)imido]-AMPs labeled with various fluorescent dyes: α-[(6-Aminohexyl)imido]-AMP-AZDye647 α-[(6-Aminohexyl)imido]-AMP-Cy5 α-[(6-Aminohexyl)imido]-AMP-AZDye555 α-[(6-Aminohexyl)imido]-AMP-Cy3 α-[(6-Aminohexyl)imido]-AMP-AZDye488
Aug 09, 2025
New: 2’,5’-GpAp
2’,5’-GpAp is now available that can be used as a negative control for 2’,3’-cGAMP due to its linear conformation.
Jul 09, 2025
Terminal fluorescently labeled deoxynucleoside hexaphosphates (dN6Ps) - Key components of long-read sequencing technologies
Terminal fluorescently labeled dN6Ps have been established as key components of long-read sequencing technologies such as single-molecule real-time sequencing (SMRT).
read moreJul 04, 2025
Now available: Cap analog m7GP32'-OmA
We extended our portfolio of RNA Cap Analogs: m7GP32'-OmA
Jul 04, 2025
Extended portfolio of fluorescently labeled ATPs
We now offer Fluorescently labeled 7-Propargylamino-7-Deaza-ATPs. They are excellent substrates for T7 RNA Polymerase - mediated in vitro transcription.
Apr 14, 2025
Now available: 2'-O-(2-Methoxyethyl)-NTPs
We extended our portfolio of 2'-O-methylated NTPs: 2'-O-MOE-ATP, 2'-O-MOE-GTP, 2'-O-MOE-CTP and 2'-O-MOE-UTP
Apr 03, 2025
Exploring the Diversity of Cyclic Di- and Trinucleotides – Key Players in Cellular Signaling
Interested in cyclic dinucleotides (CDNs) and trinucleotides (CTNs) beyond the classics such as c-diGMP or c-diAMP? Read more...
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Mar 04, 2025
Enhance amplification & sequencing results with 7-Deaza-dGTP and N4-Methyl-dCTP – Bulk amounts available!
7-Deaza-dGTP and N4-Methyl-dCTP are valuable nucleotide analogs used in amplification and sequencing applications of GC-rich DNA regions. Read more...
read moreFeb 17, 2025
Extended portfolio of 2',3'-Cyclic Nucleotide Monophosphates (2',3'-cNMPs)
In addition to 2',3'-cCMP, we now offer 2',3'-cUMP, 2',3'-cAMP and 2',3'-cGMP as well.
Nov 12, 2024
Now available: Fluorescent gamma-phosphate modified dNTPs
Check out our gamma-phosphate Cy3-labeled dNTPs: γ-(6-Aminohexyl)-dCTP-Cy3 γ-(6-Aminohexyl)-dTTP-Cy3 Contact us if you are interested in corresponding fluorescent conjugates.
Sep 09, 2024
Black Hole Quencher™: True dark quenchers without native emission
Jena Bioscience now offers BHQ-1™-, BHQ-2™- and BHQ-10™- labeled nucleotides to quench fluorescence across different spectral ranges. Read more...
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Jul 31, 2024
5-Methylcytidine modification increases self-amplifying RNA effectiveness
Katalin Karikó‘s and Drew Weissman‘s Nobel Prize-winning concept of nucleoside base modifications as basis for the development of effective mRNA vaccines has been successfully applied to self-amplifying RNA (saRNA). Read more...
read moreJul 03, 2024
Now available: Amine-functionalized nucleotide hexaphosphates (dN6P)
zeta-(6-Aminohexyl)-dA6P zeta-(6-Aminohexyl)-dG6P zeta-(6-Aminohexyl)-dC6P zeta-(6-Aminohexyl)-dT6P Interested in corresponding fluorescent conjugates? Contact us!
Jul 03, 2024
Extended portfolio of 3'-O-modified dNTPs
We now offer the complete set of 3'-phosphate-dNTPs such as 3'-Phosphate-dATP, 3'-Phosphate-dCTP, 3'-Phosphate-dGTP and 3'-Phosphate-dTTP.
Jun 13, 2024
Fluorescein-nucleotide conjugates for efficient nucleic acid labeling
We extended our portfolio of Fluorescein-labeled nucleotides for non-radioactive labeling of nucleic acids.
read moreMay 27, 2024
Extended DNP (Dinitrophenol)-labeled nucleotide portfolio
Check out our DNP (Dinitrophenol)-labeled nucleotides for efficient non-radioactive labeling of RNA and DNA: Aminoallyl-UTP-DNP Aminoallyl-dUTP-DNP Aminoallyl-CTP-DNP Aminoallyl-dCTP-DNP
May 16, 2024
Now available: High concentration labeled nucleotides for efficient DNA and RNA Labeling
Cy3-,Cy5- and Biotin-labeled nucleotides with increased concentration have now been added to our catalog. Check out our portfolio here!
read moreMay 15, 2024
GC-rich DNA regions: Enhance amplification & sequencing resolution
In addition to 7-Deaza-dGTP and dITP, we now offer N4-Methyl-dCTP that can be used as dCTP substitute.
Feb 19, 2024
Novel fluorescent probes with improved stability and affinity for Gαi1 protein
A new generation of GTP analogs labeled with 5-FAM show improved hydrolytic stability and binding affinity for Gαi1 protein compared to commonly used MANT and BODIPY FL GTPγS. Read more...
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Mar 23, 2023
Efficient RNA Labeling with abberior® STAR dyes
Efficient preparation of abberior® STAR dye-labeled RNA is now easily achievable via in vitro transcription. Read more...
read moreMar 18, 2023
Now available: abberior® dye-labeled nucleotides
Select one of our catalog products UTP labeled with abberior® STAR RED dUTP labeled with abberior® STAR RED or contact us if you are interested in a different abberior® dye-nucleotide conjugate.
Jan 25, 2023
N1-Methylpseudouridine: Increase mRNA vaccine effectiveness
Evidence suggests that N1-Methylpseudouridine modification increases mRNA vaccine effectiveness. Read more... Research suggests that incorporation of N1-Methylpseudouridine increases mRNA vaccine effectiveness through enhanced protein expression combined with low immunogenicity. Read more...
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Nov 22, 2022
mRNA quality control: Easy detection of dsRNA impurities
Double-stranded RNA (dsRNA) is a major impurity of therapeutic mRNA produced by in vitro transcription. Impurity levels of this transcriptional by-product need to be tightly monitored in mRNA production lots to ensure efficient mRNA expression and to reduce the risk of undesired high immunogenicity.
read moreMay 17, 2022
Fishing for Glyco-Proteins
Identify and isolate O-GlcNAc modifications on glyco-proteins using UDP-GalNAz! Read more...
read moreNov 18, 2021
One-step 3'-End RNA Labeling with AZDyes
One-step labeling of short 3'-End AZDye modified RNA is now easily achievable.
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Sep 21, 2021
Phosphorothioate-modified (m)RNA: Improved stability & enhanced translation efficiency
Phosphorothioate-modified (m)RNA is conveniently prepared by enzymatic incorporation of NTPαS thus generating (m)RNA with improved stability and translation efficiency profile. Read more...
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Jan 12, 2021
Selective mitochondrial DNA staining: PdG
Visualize cellular mtDNA clearly and selectively with PdG (6-O-propynyl-dG) and see the advantages over 5-ethynyl-dU! Read more...
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Sep 09, 2020
RNA-Protein Photocrosslinking: Site- and sequence-specific Tracking
Explore the advantages of using 4-Thio-uridine containing products to identify RNA-protein interactions both in cells and in vitro!
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Mar 12, 2020
Explore the ATP binding proteome!
Explore the ATP binding proteome with our new Acyl-ATP probes, ATP-acetyl-hex-Biotin and ATP-acetyl-Desthiobiotin!
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Jan 08, 2020
12 New non-hydrolyzable nucleotides available!
We have expanded our portfolio of non-hydrolyzable nucleotides with 12 new compounds to study protein-protein interactions, structure and dynamics of protein-nucleotide complexes, and NTPase kinetics. Find more information here!
read moreDec 05, 2019
Probes for ATP binding proteins
We now offer Probes for ATP binding proteins: ATP-acetyl-hex-Biotin and ATP-acetyl-Desthiobiotin.
Oct 24, 2019
cGAMPs: The Second Messengers you need
cGAMPs are cyclic dinucleotides (CDNs) consisting of a 12-or-13-membered ring scaffold and two ribonucleotides. To date, two cGAMPs have been discovered in nature - 2‘,3‘-cGAMP and 3‘,3‘-cGAMP. Join the exciting field of cyclic dinucleotide signaling and expand your molecular toolbox!
read moreAug 12, 2019
Biotin-16-ddUTP is now available for:
3'-end labelingMALDI-TOF MS-based SNP typing assaystandard nick translation reaction for tumor DNA labelling during comparative genomic hybridizationBiotinylation of in vitro transcribed tmRNA during surface plasmon resonance (SPR) technique
Jul 05, 2019
Available again!
2-Ethynyl-Adenosine-NAD+ (2-EA-NAD+), a clickable probe for the detection of protein ADP-ribosylation, is now back in our catalog.
Jun 13, 2019
Swiss Army Knives for NTPase Analysis
BODIPY® FL NTPs are multipurpose tools forNucleotide binding studies on Gα, Ras, FHIT and RNAse L proteinsGTPase activity assaysActivity-based covalent labeling of bacterial two-component systemsSee how it works!
read moreJan 18, 2019
Shining a Spotlight on Nucleotide-Protein Interactions
Fluorescent nucleotide conjugates are analytical tools with exceptional versatility. By covering a plethora of fluorescence-based techniques they are applied as drug screening probes, in cytoskeletal imaging and in nucleotide-protein interaction studies. Learn more!
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Oct 30, 2018
Nucleotide Chemotherapeutics – A Success Story Goes On!
Antiviral and Cytostatic Nucleotide Analogs toStudy pharmacologyElucidate metabolic pathwaysImprove the potencyCheck out our range of nucleotide chemotherapeutic derivatives!
read more
Sep 24, 2018
4-Seleno-dTTP: NGS-based mapping of m6A-modified RNA sites
4SedTTP permits the identification of methylated adenosinesat single nucleotide resolutionwithout antibodiesin an NGS-based approachHow it works:
read moreSep 12, 2018
4-Selenothymidine-5'-triphosphate
4SedTTP for precise antibody-independent m6A identification is now available.
Aug 31, 2018
Nucleotides & qPCR: Easy online Search
Looking for nucleotides based on their structure or for a specific application? Want to find the most suitable qPCR mix for your assay?
read moreJul 03, 2018
dNTP Guide – High Performance Nucleotides
Because nucleotides don't get better than this. Click here!
Jun 21, 2018
New in Click Chemistry: 2'-Azido-2'-dATP
We added 2'-Azido-2'-dATP to our Click Chemistry section. For more details please click here.
Jun 04, 2018
Di-Adenosine Polyphosphates: Bacterial Signaling Molecules
The mode of ApnA function in bacterial signaling is awaiting its elucidation. Click to see what our compounds can contribute!
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May 16, 2018
Why are you still using radioactively labeled Probes?
If you’re running experiments like Northern and Southern blots, or EMSA, you’re probably using radioactively labeled probes, right? There’s good news and bad news. The bad news is that radioactively labeled probes have a limited half-life and require special laboratory equipment... DISCOVER THE GOOD NEWS!
read moreMay 09, 2018
New: 3' End Oligonucleotide Labeling Kits
3' End Oligonucleotide Labeling Kits for preparation of Biotin- or Digoxigenin-labeled ssDNA/oligonucleotide probes are now available.
May 08, 2018
High Concentration Biotin-11-UTP
We now offer 75 mM Biotin-11-UTP in addition to our standard 10 mM Biotin-11-UTP solution.
Apr 18, 2018
FSBA and FSBG: Universal Traps for Triphosphate-Cleaving Enzymes
Probing ATPases, G-Proteins, Kinases, and Polymerases with Sulfonyl Fluoride Nucleosides – See how it can help your research!
read moreApr 12, 2018
Biotin-14-dATP and -dCTP for Hi-C Experiments
Hi-C experiments allow analyses of spatial genome organization. Adjacent genome regions are tagged by enzymatic biotinylation using Biotin-14-dATP or Biotin-14-dCTP and subsequently identified by (next generation) sequencing.
read moreFeb 27, 2018
c-di-AMP – The Messenger You Can't Ignore
Research on bacterial second messengers has recently experienced tremendous progress, and cyclic di-AMP (c-di-AMP) is one of the rising stars.
read moreFeb 16, 2018
New DNA/RNA labeling nucleotides
We now offer Biotin-14-dCTP, Biotin-11-ATP and dUTP-XX-ATTO-425 for enzymatic DNA/RNA labeling. Nucleotide Selector for DNA/RNA Labeling
Jan 16, 2018
Now available: c-di-AMP
cyclic-di-AMP - The pleiotropic bacterial second messenger now adds to our cyclic-di-Nucleotide portfolio.
