For in vitro use only!
Shipping: shipped on blue ice
Storage Conditions: store at -20 °C
Shelf Life: 12 months
Molecular Formula: C47H84O16P2(free acid)
Molecular Weight: 967.11 g/mol (free acid)
Purity: ≥ 99 %
Phosphatidylinositol-4-phosphate is one of the in vitro substrates for PI3-kinases. Phosphatidylinositol 3-kinase is a lipid kinase that phosphorylates the inositol ring of phosphatidylinositol-4-phosphate and related compounds at the 3’-OH position. PIP can be used as a substrate for PI3K lipid kinase activity assay together with a mix of PI, PIP2, PC, PE, PS and SM.
Vanhaesebroeck et al. (2001) Synthesis and function of 3-phosphorylated inositol lipids. Ann. Rev. Biochem. 70:535.
Balla (2001) Pharmacology of phosphoinositides, regulators of multiple cellular functions. Curr. Pharm. Des. 7:475.
Wymann (2003) Phosphoinositide 3-kinase signalling which way to target? Trend Pharmacol. Sci. 24:323.
Foukas et al. (2002) Direct effects of caffeine and theophylline on p110 delta and other phosphoinositide 3-kinases. Differential effects on lipid kinase and protein kinase activities. J. Biol. Chem. 277:37124.