Incorrect folding and insufficient solubility - resulting in compromised biological activity - are the major shortcomings of prokaryotic expression systems. Due to LEXSY’s fully eukaryotic protein synthesis/folding/modification machinery most proteins of higher organisms expressed in LEXSY are correctly folded and processed and therefore, are obtained in a fully functional state.
| Protein | Localisat. | Origin | Reference | Downloads |
|---|---|---|---|---|
| Erythropoietin | sec | human | Breitling et al. 2002 | |
| Surface Antigen 1& 2 | sec | Toxoplasma gondii | Ebert et al. 2007 not publ. | |
| Proprotein Convertase 4 | sec | rat | Basak et al. 2008 | |
| Laminin-332 | sec | human | Phan et al. 2009 | |
| Cu/Zn superoxide dismutase | cyt | human | Gazdag et al. 2010 | |
| Tissue Plasminogen Activator | sec | human | Hemayatkar et al. 2010 | |
| N-Acetyl Serotonin Methyl Transferase (ASMT) | cyt | human | Ben-Abdallah et al. 2010 | |
| Hydroxynitrile Lyase (MeHNL) | cyt | cassava plant | Dadashipour et al. 2011 | |
| Coagulation factor VII | cyt | human | Mirzaahmadi et al. 2011 |
For a short summary of expression data obtained, please, refer to the LEXSY Brochure page 18
