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Protein Kinase Inhibitor



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INH-004 5 mg 21,40 Add to Basket/Quote Add to Notepad
Structural formula of Myricetin (3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-1-benzopyran-4-one, 3,3',4',5,5',7-Hexahydroxyflavone)
Structural formula of Myricetin

For in vitro use only!

Shipping: shipped on blue ice

Storage Conditions: store at -20 °C
avoid freeze/thaw cycles

Shelf Life: 12 months

Molecular Formula: C15H10O8

Molecular Weight: 318.24 g/mol

CAS#: 529-44-2

Purity: ≥ 95 %

Form: lyophilised

Solubility: 10 mg/ml soluble in DMSO, 1 mg/ml soluble in Ethanol. Insoluble in Acetic Acid.

Myricetin is a flavonoid that differs from quercetin only by the addition of a hydroxyl at the 5’-OH of the phenyl moiety. It shows cytotoxic activity against several human leukemic cell lines in vitro.
It strongly inhibits yeast a-glucosidase, glyoxalase I in vitro, cow's milk xanthine oxidase, and PI3-Kinase (IC50 = 1.8 μM).
Myricetin both modulates Na+/K+-ATPase-induced vasodilatation acting as a functional inhibitor of Na+/K+-ATPase activity and activates protein kinases, including PKC, to induce contraction. These effects appear to be related to the activation of PGH2-TXA2 receptors on vascular smooth muscle by the TXA2 released from endothelium.

Selected References:
Walker et al. (2000) Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine. Mol. Cell. 6:909.
Jimenez et al. (2002) Involvement of protein kinase C and Na+/K+ - ATPase in the contractile response induced by myricetin in rat isolated aorta. Planta Med. 68:133.
Dimas et al. (2000) Biological activity of myricetin and its derivatives against human leukemic cell lines in vitro. Pharmacol Res. 42:475.
Ong et al. (1997) Biological effects of myricetin. Gen. Pharmacol. 29:121.