Protein Kinase Inhibitor
3,3',4',5,7-Pentahydroxyflavone dihydrate, sodium salt
For in vitro use only!
Shipping: shipped on blue ice
Storage Conditions: store at -20 °C
Shelf Life: 12 months
Molecular Formula: C15H10O7·2H2O
Molecular Weight: 338.26 g/mol
EC number: 204-187-1
Purity: ≥ 98 %
Solubility: 30 mg/ml soluble in DMSO, 2 mg/ml in Acetic Acid and Aqueous Alkaline.
Quercetin is a flavonoid with anticancer activity. It inhibits mitochondrial ATPase, phosphodiesterase, PI3-kinase activity (IC50 = 3.8 μM) and slightly PIP kinase activity. It has antiproliferative effects on cancer cell lines; reduces cancer cell growth via type II estrogen receptors and has been reported to arrest human leukemic T cells in late G1phase of the cell cycle.
It induces apoptosis in K562, Molt-4, Raji, A549 and MCAS tumor cell lines.
Walker et al. (2000) Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine. Mol. Cell. 6:909.
De et al. (2004) Comparative evaluation of cancer chemopreventive efficacy of alpha-tocopherol and quercetin in a murine model. J. Exp. Clin. Cancer Res. 23:251.
Picq et al. (1982) Pentasubstituted quercetin analogues as selective inhibitors of particulate 3':5'-cyclic-AMP phosphodiesterase from rat brain. J. Med. Chem. 25:1192.
Nguyen et al. (2004) The role of activated MEK-ERK pathway in quercetin-induced growth inhibition and apoptosis in A549 lung cancer cells. Carcinogenesis. 25:647.
Mertens-Talcott et al. (2003) Low concentrations of quercetin and ellagic acid synergistically influence proliferation, cytotoxicity and apoptosis in MOLT-4 human leukemia cells. J. Nutr. 133:2669.