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Protein Kinase Inhibitor

3,3',4',5,7-Pentahydroxyflavone dihydrate, sodium salt

Cat. No. Amount Price (EUR) Buy / Note
INH-003 100 mg 23,78 Add to Basket/Quote Add to Notepad
Structural formula of Quercetin (2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one, 3,3',4',5,7-Pentahydroxyflavone dihydrate, sodium salt)
Structural formula of Quercetin

For in vitro use only!

Shipping: shipped on blue ice

Storage Conditions: store at -20 °C

Shelf Life: 12 months

Molecular Formula: C15H10O7·2H2O

Molecular Weight: 338.26 g/mol

CAS#: 117-39-5

EC number: 204-187-1

Purity: ≥ 98 %

Form: lyophilised

Solubility: 30 mg/ml soluble in DMSO, 2 mg/ml in Acetic Acid and Aqueous Alkaline.

Quercetin is a flavonoid with anticancer activity. It inhibits mitochondrial ATPase, phosphodiesterase, PI3-kinase activity (IC50 = 3.8 μM) and slightly PIP kinase activity. It has antiproliferative effects on cancer cell lines, reduces cancer cell growth via type II estrogen receptors and has been reported to arrest human leukemic T cells in late G1phase of the cell cycle.
It induces apoptosis in K562, Molt-4, Raji, A549 and MCAS tumor cell lines.

Selected References:
Walker et al. (2000) Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine. Mol. Cell. 6:909.
De et al. (2004) Comparative evaluation of cancer chemopreventive efficacy of alpha-tocopherol and quercetin in a murine model. J. Exp. Clin. Cancer Res. 23:251.
Picq et al. (1982) Pentasubstituted quercetin analogues as selective inhibitors of particulate 3':5'-cyclic-AMP phosphodiesterase from rat brain. J. Med. Chem. 25:1192.
Nguyen et al. (2004) The role of activated MEK-ERK pathway in quercetin-induced growth inhibition and apoptosis in A549 lung cancer cells. Carcinogenesis. 25:647.
Mertens-Talcott et al. (2003) Low concentrations of quercetin and ellagic acid synergistically influence proliferation, cytotoxicity and apoptosis in MOLT-4 human leukemia cells. J. Nutr. 133:2669.