5’-capping and epigenetic nucleotide modifications are critical for efficient translation and reduced immunogenicity of synthetic mRNA. The classic combination of modifications consists of ARCA, 5-methylcytidine and pseudouridine. Promising extensions of the mRNA modification toolbox are available. Read more…



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Modified mRNA synthesis beyond the classics


5’-capping and epigenetic nucleotide modifications are critical for efficient translation and reduced immunogenicity of synthetic mRNA.

The classic combination of modifications consists of ARCA, 5-methylcytidine and pseudouridine. Promising extensions of the mRNA modification toolbox are available. Read more…
Read more...


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