LCP crystallization is the most popular method for membrane protein structure determination. Experiments are typically done in batch format. However, it is well known from the crystallization of soluble proteins that vapor diffusion can be a lot more powerful. The controlled in meso phase (CIMP) method combines the benefits of LCP and vapor diffusion to push membrane protein crystallization to new limits . The patent-pending In-Meso Crystallization Plate provides an easy start with this revolutionary method.
Relationship between dilution of precipitant solution in the protein well, water content of the equilibrated protein drop, and the in meso phase that can be reached in a given experiment. Adapted from .
 Kubicek et al. (2012) Controlled In Meso Phase Crystallization - A Method for the Structural Investigation of Membrane Proteins. PLoS ONE 7:e35458.