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Screening Membrane Proteins - LCP Lipids

Membrane protein crystallization using lipidic cubic phase (LCP) is proving to be a successful methodology for obtaining good quality diffracting crystals from membrane proteins due to its membrane native-like environment [1].

Monoolein is the first choice lipid for performing an LCP crystallization experiment. However, since the nature of the lipid determines the nature of the LCP, it’s worth varying the LCP characteristics by screening different lipids, especially when initial crystallization attempts with monoolein have failed [2,3].

The LCP Host Lipids listed below are suited to form a stable lipidic cubic phase for membrane protein crystallization.

Discover the LCP method and benefit from our bundle offers!*

Bundle Option Content Discount granted Final Price
Long lipids bundle 1x X-LCP-101
1x X-LCP-102
1x X-LCP-103
1x X-LCP-104
25 % 543 €
Short lipids bundle 1x X-LCP-105
1x X-LCP-106
1x X-LCP-107
25 % 887 €
All in bundle 1x X-LCP-101
1x X-LCP-102
1x X-LCP-103
1x X-LCP-104
1x X-LCP-105
1x X-LCP-106
1x X-LCP-107
30 % 1335 €

* Valid until March 31, 2017; please indicate the bundle option when placing your order!


References

    [1] Landau and Rosenbusch (1996) Lipidic cubic phases: a novel concept for the crystallization of membrane proteins. PNAS 93:14532.
    [2] Caffrey (2015) A comprehensive review of the lipid cubic phase or in meso method for crystallizing membrane and soluble proteins and complexes. Acta Cryst F 71:3.
    [3] Caffrey and Cherezov (2009) Crystallizing Membrane Proteins Using Lipidic Mesophases. Nat Protoc. 4(5):706.