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Screening Membrane Proteins

Membrane proteins play a key role to understand the complex interactions that allow for unicellular and multicellular life up to humans. They further possess a huge potential for the treatment of human diseases and structure determination is the first bottleneck on this promising and challenging way.
This section comprises specialized screens and tools to crystallize membrane proteins solubilized by detergents as well as membrane proteins in the lipidic cubic phase (LCP). Amphipol A8-35 is a surfactant especially useful for sample preparation in Cryo-EM - to stabilize membrane proteins in a detergent-free aqueous solution.