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Cryo-EM - QUANTIFOIL™ Holey Carbon Films

QUANTIFOIL™ is a holey carbon film with a thickness of about 12 nm, that is applied on a standard copper or gold electron microscopy grid and provides an ideal support for biological samples in Cryo-EM techniques[1-6].
The supporting mesh (copper or gold) is available with distinct numbers. Higher mesh numbers (400) indicate closely spaced bars and provide higher stability, whereas lower numbers (200) provide larger free faces.
The QUANTIFOIL™ carbon film has circular holes of defined size and interspace, e.g. R 2/1 (pictured) has holes of 2 µm diameter with an interspace of 1 µm in both dimensions. Higher magnifications usually require smaller holes and vice versa.

You have the following options to choose from:


  • R 1.2/1.3 (1.2 µm hole diameter/1.3 µm interspace)
  • R 2/1 (2 µm hole diameter/1 µm interspace)
  • R 2/2 (2 µm hole diameter/2 µm interspace)
Supporting mesh material
  • Copper
  • Gold
Supporting mesh number
  • 200
  • 300
  • 400

Selected Recent Literature Citations of QUANTIFOILs™

[1] Park et al. (2017) Structure of a CLC chloride ion channel by cryo-electron microscopy. Nature 541:500.
[2] Kalynych et al. (2017) Cryo-EM study of slow bee paralysis virus at low pH reveals iflavirus genome release mechanism. PNAS 114:598.
[3] Ekiert et al. (2017) Architectures of Lipid Transport Systems for the Bacterial Outer Membrane. Cell 169:273.
[4] Beniac et al. (2017) Structure of the Ebola virus glycoprotein spike within the virion envelope at 11 Å resolution. Sci. Rep. DOI: 10.1038/srep46374.
[5] Lokareddy et al. (2017) Portal protein functions akin to a DNA-sensor that couples genome-packaging to icosahedral capsid maturation. Nat. Commun. DOI: 10.1038/ncomms14310.
[6] Davies et al. (2017) Cryo-EM analysis of a domain antibody bound rotary ATPase complex. J. Struct. Biol. 197:350.