Chloroquine diphosphate salt
For in vitro use only!
Shipping: shipped at ambient temperature
Storage Conditions: store at 4 °C
Shelf Life: 12 months
Molecular Formula: C18H26CIN3·2H3PO4
Molecular Weight: 515.9 Da
EC number: 200-055-2
Solubility: soluble in water (50 mg/ml)
During internalization some mechanisms lead to formation of intracellular vesicles. For release of cargo from these vesicles they must be destabilized. For this purpose chloroquine have been proven effective when added to the medium. Add chloroquine to the serum containing medium to achieve a concentration of 150 μM.
For more information see general manual (4.2.2).
Melting point: 193 °C
Harmful if swallowed. Do not breathe dust. Avoid contact with skin and eyes. Target organ(s): Eyes. Heart. Light sensitive.
Clarke's Isolation and Identification of Drugs, Ed. by Moffat, A. C. et al., The Pharmaceutical Press ,London (1986)
Krajewski, W.A. (1999) Effect of In Vivo Histone Hyperacetylation on the State of Chromatin Fibers. J. Biomol. Struct. Dyn.16:1097.
Harashima et al. (2011) Roles of the PI3K/Akt pathway and autophagy in TLR3 signaling-induced apoptosis and growth arrest of human prostate cancer cells. Cancer Immunology, Immunotherapy.
Availability Restriction: Exclusively distributed in Japan by Greiner BioOne