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LEXSY - Eukaryotic protein expression in Leishmania tarentolae

The unicellular kinetoplast protozoan Leishmania tarentolae, isolated from the Moorish gecko Tarentola mauritanica, not pathogenic to mammalians (Biosafety level 1) – was turned into the protein-producing host of our eukaryotic protein expression system LEXSY:

  • eukaryotic host as easy to handle as E. coli: no specific labware, no cell biology equipment required
  • fully eukaryotic protein expression machinery with post-translational modifications, including glycosylation and disulfide bond formation
  • shuttle vectors: cloning in E. coli, expression in LEXSY host
  • constitutive or inducible, intracellular or secretory expression of target proteins
  • stable expression strains for constant protein production