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Prenylation - GGTase-I Substrates and Related Proteins

Since the initial discovery of prenylated fungal proteins, many more proteins have been demonstrated to contain a prenyl modification. Today it's well-known, that protein prenylation affects up to 2% of the proteins in the mammalian proteome.

The proteins listed below are GGTase-I substrates and corresponding proteins.
A geranylgeranyl moiety is attached to the cysteine of the so called CaaX box, a C-terminal motif required for prenylation.
Please note that deletion mutants with truncated C-terminus are not recognized by the protein geranylgeranyltransferase and will thus not be prenylated.