» Sign in / Register

DBCO Reagents - Bifunctional Reagents

Dibenzocyclooctyne (DBCO)*-containing bifunctional reagents can be used for the introduction of

  • a functional group to Azide-labeled molecules via Cu(I)-free strain-promoted Alkyne-Azide Click Chemistry (SPAAC)
  • an DBCO group to various targets e.g. via NHS Ester- or Maleimide-based chemistry

*DBCO is also known as ADIBO (= Azadibenzocyclooctyne) or DIBAC (= Dibenzoazacyclooctyne)

 

Table 1: Available DBCO-containing Bifunctional Reagents

Functional GroupsDBCOFunctional GroupsDBCO
NHS esterDBCO-NHS ester
DBCO-PEG4-NHS ester
DBCO-Sulfo-NHS ester
Acid (-COOH) DBCO-Acid
MaleimideDBCO-Maleimide
DBCO-PEG4-Maleimide
Amine (-NH2)DBCO-Amine
DBCO-PEG4-Amine
Alcohol (-OH) DBCO-PEG3-Alcohol
DBCODBCO-PEG4-DBCO