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Alkyne-containing 2'-Deoxy-nucleosides

Alkyne-containing nucleosides can be labeled with Azide-containing reporter molecules via a Cu(I)-catalyzed Azide-Alkyne Click Chemistry reaction (CuAAC).

A number of cell-permeable CLICK-functionalized nucleosides are suitable for DNA synthesis monitoring → Click Chemistry, RNA synthesis monitoring → Click Chemistry, the analysis of poly A tail dynamics → Click Chemistry or Protein synthesis monitoring → Click Chemistry.