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Acetylene-PEG4-Biotin

Product Cat. No. Amount Price (EUR) Buy / Note
Acetylene-PEG4-Biotin CLK-TA105-25 25 mg 81,49 Add to Basket/Quote Add to Notepad
Acetylene-PEG4-Biotin CLK-TA105-1000 1 g 1.192,30 Add to Basket/Quote Add to Notepad
Acetylene-PEG4-Biotin CLK-TA105-100 100 mg 289,32 Add to Basket/Quote Add to Notepad

Structural formula of Acetylene-PEG4-Biotin

For research use only!

Shipping: shipped at ambient temperature

Storage Conditions: store at -20 °C

Shelf Life: 12 months

Molecular Formula: C21H35N3O6S

Molecular Weight: 457.58 g/mol

CAS#: 1262681-31-1

Purity: > 90 % (H NMR)

Form: white powder

Solubility: Chloroform, DCM, DMF, DMSO, THF

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Description:
Acetylene-PEG4-Biotin is suitable for the introduction of a biotin moiety to Azide-labeled biomolecules via Cu(I)-catalyzed Alknye-Azide (CUAAC) reaction.

The hydrophilic PEG4 linker [26.4 Å (22 atoms)] reduces or eliminates aggregation and precipitation during the labeling process by increasing the hydrophilicity of the target molecule. It furthermore enhances the accessibility of the biotin moiety and thus the detection efficiency of the biotinylated molecule via fluorescent or HRP-labeled streptavidin or its affinity purification via streptavidin agarose.

Due to the extremely high affinity of biotin towards streptavidin (KD = 10-15 M), the biotinylated molecule/streptavidin-interaction is essentially irreversible under physiological conditions.