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CLK-028-25 25 mg 381,27 Add to Basket/Quote Add to Notepad
Structural formula of 6-Methyl-Tetrazine-PEG4-Biotin
Structural formula of 6-Methyl-Tetrazine-PEG4-Biotin

For research use only!

Shipping: shipped at ambient temperature

Storage Conditions: store at -20 °C

Shelf Life: 12 months after date of delivery

Molecular Formula: C31H46N8O7S

Molecular Weight: 674.81 g/mol

Purity: > 95 % (HPLC)

Form: red oil

Solubility: DMSO, DMF, DCM, MeOH

6-Methyl-Tetrazine-PEG4-Biotin is suitable for the introduction of a biotin moiety to cyclooctene (e.g. TCO)-labeled biomolecules via Cu(I)-free Click Chemistry reaction.

The hydrophilic PEG4 linker reduces or eliminates aggregation and precipitation during the labeling process by increasing the hydrophilicity of the target molecule. It furthermore enhances the accessibility of the biotin moiety and thus the detection efficiency of the biotinylated molecule via fluorescent or HRP-labeled streptavidin or its affinity purification via streptavidin agarose.

Due to the extremely high affinity of biotin towards streptavidin (KD = 10-15M), the biotinylated molecule/streptavidin-interaction is essentially irreversible under physiological conditions.