For research use only!
Shipping: shipped on blue ice
Storage Conditions: store at -20 °C
Shelf Life: 12 months after date of delivery
Molecular Formula: C10H15NO3
Molecular Weight: 197.23 g/mol
Exact Mass: 197.11 g/mol
Purity: ≥ 90 % (HPLC)
Form: white to off-white powder
Solubility: 80 % EtOH / 0.2M NH4OH up to 100 mM
The norbornene-tetrazine click reaction is ideally suited for protein labeling in living cells.
The inverse-electron demand Diels-Alder reaction of a novel amino acid bearing a norbornene moiety 3-norbornene-L-serine with tetrazines is a bioorthogonal reaction that possesses exceptional kinetics (0.59 M-1s-1) and selectivity. Both the carboxylic acid and the amine functionalities on 3-norbornene-L-serine make it an ideal linker for the functionalization of diverse compounds by using N-hydroxysuccinimide ester and amine-carboxylic acid coupling system.
Prepare the stock solution of 3-norbornene-L-serine immediately before use.
Knall, A.C. et al.(2014) Kinetic studies of inverse electron demand Diels-Alder reactions (iEDDA) of norbornenes and 3,6-dipyridin-2-yl-1,2,4,5-tetrazine. Tetrahedron Lett 55(34):4763.
Lukesch, M. (2019) Novel amino acids bearing a norbornene moiety. U.S. Patent WO2019016354A1.