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DBCO-containing PEGylation Reagents

Dibenzocyclooctyne (DBCO)*-modified polyethylene glycol (PEG) polymers can be used for the introduction of a PEG moiety ("PEGylation") to Azide-tagged biomolecules via Cu(I)-free strain-promoted Alkyne-Azide Click Chemistry (SPAAC), respectively.

PEGylation of biomolecules such as proteins increases their water solubility and often improves their pharmacokinetic properties e.g. by a reduced immunogenicity and antigenicity.

*DBCO is also known as ADIBO (= Azadibenzocyclooctyne) or DIBAC (= Dibenzoazacyclooctyne)