Dibenzocyclooctyne (DBCO)*-modified polyethylene glycol (PEG) polymers can be used for the introduction of a PEG moiety ("PEGylation") to Azide-tagged biomolecules via Cu(I)-free strain-promoted Alkyne-Azide Click Chemistry (SPAAC), respectively.
PEGylation of biomolecules such as proteins increases their water solubility and often improves their pharmacokinetic properties e.g. by a reduced immunogenicity and antigenicity.
*DBCO is also known as ADIBO (= Azadibenzocyclooctyne) or DIBAC (= Dibenzoazacyclooctyne)
