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Alkyne-containing (Desthio) Biotinylation Reagents

Alkyne-containing (desthio) biotinylation reagents can be used for the labeling of Azide-tagged biomolecules via a Cu(I)-catalyzed Azide-Alkyne Click Chemistry reaction (CuAAC).

A number of (desthio) biotinylation reagents with

  • improved solubility & detection characteristics (PEG-linker for increased molecule solubility & optimal streptavidin binding)
  • different cleavability characteristics (chemically or photocleavable linker)
are available to fit specific application & molecule requirements.


Table 1: Available Alkyne-containing (Desthio) Biotinylation Reagents

Biotin with chemically cleavable linkerDiazo Biotin-Alkyne
Dde Biotin-Alkyne
Diol Biotin-Alkyne
Biotin with photocleavable linkerPhotocleavable Biotin-Alkyne