"AquIRE reveals the mechanisms of clinically induced RNA damage and the conversation and dynamics of glycoRNAs." by Zhang et al.[1] (Nucleic Acid Research, Feb 27, 2026) is our featured scientific article for February.
RNA is not only a messenger molecule – it is chemically dynamic and susceptible to damage. While DNA damage has been studied extensively, much less is known about how RNA is modified or damaged under clinical conditions such as chemotherapy or oxidative stress.
In this study, the authors introduce AquIRE, a high-resolution method that enables precise detection and mapping of RNA damage. Using this approach, they show that clinically induced RNA damage follows defined mechanistic patterns rather than occurring randomly.
Beyond damage mapping, the study also investigated glycoRNAs – RNA molecules carrying glycan modifications. The authors demonstrated that glycoRNAs are evolutionary conserved and dynamically regulated within cells, suggesting functional relevance beyond a rare biochemical curiosity.
This work expands our understanding of RNA biology in two important directions:
Want to read more: access the full article here!
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[1] Zhang et al. (2026) AquIRE reveals the mechanisms of clinically induced RNA damage and the conversation and dynamics of glycoRNAs. Nucleic Acid Research, https://doi.org/10.1093/nar/gkag080
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